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CAS 433-19-2
1,4-Bis(trifluoromethyl)benzene
Codes：(V)91299-1-b
Application context (from source-drug indications)
疟原虫感染青蒿琥酯/磷酸咯萘啶新型冠状病毒感染青蒿琥酯/磷酸咯萘啶恶性疟青蒿琥酯/磷酸咯萘啶疟原虫感染青蒿琥酯/盐酸甲氟喹恶性疟青蒿琥酯/盐酸甲氟喹
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 青蒿琥酯/磷酸咯萘啶Artesunate/Pyronaridine Phosphate | Tier C — Watch / trade | - |
| 青蒿琥酯/盐酸甲氟喹Artesunate/Mefloquine Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,4-Bis(trifluoromethyl)benzene→1,4-Dibromo-2,5-bis(trifluoromethyl)benzene→(4-Hydroxyphenyl)boronic acid→2(2),2(5)-Bis(trifluoromethyl)[1(1),2(1):2(4),3(1)-terphenyl]-1(4),3(4)-diol→1(3),1(5),3(3),3(5)-Tetrabromo-2(2),2(5)-bis(trifluoromethyl)[1(1),2(1):2(4),3(1)-terphenyl]-1(4),3(4)-diol→1(3),1(5),3(3),3(5)-Tetrabromo-1(4),3(4)-dimethoxy-2(2),2(5)-bis(trifluoromethyl)-1(1),2(1):2(4),3(1)-terphenyl→4-(Ethoxycarbonyl)phenylboronic acid→Ethyl 4-[5-[4-[3,5-bis(4-ethoxycarbonylphenyl)-4-methoxy-phenyl]-2,5-bis(trifluoromethyl)phenyl]-3-(4-ethoxycarbonylphenyl)-2-methoxy-phenyl]benzoate→4-[5-[4-[3,5-Bis(4-carboxyphenyl)-4-methoxy-phenyl]-2,5-bis(trifluoromethyl)phenyl]-3-(4-carboxyphenyl)-2-methoxy-phenyl]benzoic acid
1,4-Bis(trifluoromethyl)benzene→1,4-Dibromo-2,5-bis(trifluoromethyl)benzene→(4-Hydroxyphenyl)boronic acid→2(2),2(5)-Bis(trifluoromethyl)[1(1),2(1):2(4),3(1)-terphenyl]-1(4),3(4)-diol→1(3),1(5),3(3),3(5)-Tetrabromo-2(2),2(5)-bis(trifluoromethyl)[1(1),2(1):2(4),3(1)-terphenyl]-1(4),3(4)-diol→1(3),1(5),3(3),3(5)-Tetrabromo-1(4),3(4)-dimethoxy-2(2),2(5)-bis(trifluoromethyl)-1(1),2(1):2(4),3(1)-terphenyl→4-(Ethoxycarbonyl)phenylboronic acid→Ethyl 4-[5-[4-[3,5-bis(4-ethoxycarbonylphenyl)-4-methoxy-phenyl]-2,5-bis(trifluoromethyl)phenyl]-3-(4-ethoxycarbonylphenyl)-2-methoxy-phenyl]benzoate→4-[5-[4-[3,5-Bis(4-carboxyphenyl)-4-methoxy-phenyl]-2,5-bis(trifluoromethyl)phenyl]-3-(4-carboxyphenyl)-2-methoxy-phenyl]benzoic acid
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