CAS 500-22-1

nicotinaldehyde

Codes：CHID-001

Application context (from source-drug indications)

弥漫性大B-细胞淋巴瘤西达本胺T-细胞白血病西达本胺乳腺癌西达本胺外周T细胞淋巴瘤西达本胺前体T-淋巴母细胞性淋巴瘤白血病西达本胺结直肠癌西达本胺

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
西达本胺Chidamide	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

西达本胺原研路线steps: 3total yield: 201.2 g

nicotinaldehyde→malonic acid→(E)-3-(pyridin-3-yl)acrylic acid→4-(aminomethyl)benzoic acid→(E)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzoic acid→4-fluorobenzene-1,2-diamine

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