CAS 51-48-9

O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine

Codes: Levothyroxine Sodium-018

Application context (from source-drug indications)

ComaLevothyroxine Sodium粘液性水肿昏迷Levothyroxine SodiumHypothyroidismLevothyroxine SodiumThyroid cancerLevothyroxine SodiumHyperthyroidismLevothyroxine SodiumObesityLevothyroxine Sodium

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Levothyroxine Sodium	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Levothyroxine SodiumOptimised routesteps: 5total yield: 56.8g(Levothyroxine (API))

3,5-Diiodo-L-tyrosine→Copper(2+) bis[(2S)-2-amino-3-(4-hydroxy-3,5-diiodophenyl)propanoate]→Bis(4-methoxyphenyl)iodanium iodide→3,5-Diiodo-O-(4-methoxyphenyl)-L-tyrosine→3,5-Diiodo-4-(4-hydroxyphenoxy)-L-phenylalanine→O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine

Intermediates available on this site

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