CAS 535-75-1

(+/-)-Piperidine-2-carboxylic acid

Codes：(I)91311-1-a、(I)91311-2-a

Application context (from source-drug indications)

疼痛盐酸布比卡因/枸橼酸芬太尼

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
盐酸布比卡因/枸橼酸芬太尼Bupivacaine Hydrochloride/Fentanyl Citrate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

盐酸布比卡因/枸橼酸芬太尼优化路线steps: 3total yield: /

(+/-)-Piperidine-2-carboxylic acid→1-[(Benzyloxy)carbonyl]piperidine-2-carboxylic acid→2-Amino-1,3-dimethylbenzene→Phenyl 2-[(2,6-dimethylphenyl)carbamoyl]piperidine-1-carboxylate→(RS)-N-(2,6-Dimethylphenyl)piperidine-2-carboxamide→1-Bromobutane

盐酸布比卡因/枸橼酸芬太尼优化路线steps: 4total yield: /

(+/-)-Piperidine-2-carboxylic acid→DL-Pipecolic acid hydrochloride→Piperidine-2-carbonyl chloride hydrogen chloride→2-Amino-1,3-dimethylbenzene→(RS)-N-(2,6-Dimethylphenyl)piperidine-2-carboxamide→1-Bromobutane

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