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CAS 55299-57-5

Ethyl N,O-diacetylserinate

Codes:Ramipril-069

Application context (from source-drug indications)

高胆固醇血症阿托伐他汀钙/雷米普利高血压阿托伐他汀钙/雷米普利

Source drugs (routes using this intermediate)

DrugTierExpiry
阿托伐他汀钙/雷米普利Atorvastatin Calcium Hydrate/RamiprilTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

阿托伐他汀钙/雷米普利优化路线steps: 6total yield: 3.33g(Ramipril-074)
(+/-)-2-Amino-3-hydroxypropionic acid→DL-Serine methyl ester hydrochloride→Ethyl serinate hydrogen chloride→2-Benzamido-3-ethoxy-3-oxopropyl benzoate→2-Benzamido-3-ethoxy-3-oxopropyl benzoate→Ethyl N,O-diacetylserinate→Ethyl 2-benzamidoprop-2-enoate→Ethyl 2-(benzoylamino)acrylate→2-Acetamido-2-propenoic acid methyl ester→1-Morpholinocyclopentene→Cyclopentanone→Ethyl N-benzoyl-3-(2-oxocyclopentyl)alaninate→Ethyl N-benzoyl-3-(2-oxocyclopentyl)alaninate→(Methyl 2-(acetylamino)-3-(2-oxocyclopentyl)propanoate)→Benzyl octahydrocyclopenta[b]pyrrole-2-carboxylate hydrogen chloride→Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrogen chloride

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