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CAS 5571-36-8
(8S,13S,14S)-13-methyl-1,4,6,7,8,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17(2H)-one17-Oxo-estradiene
Codes：MIFE-001、(I)90248-6-a
Application context (from source-drug indications)
终止妊娠米非司酮/米索前列醇避孕地诺孕素/戊酸雌二醇月经过多地诺孕素/戊酸雌二醇避孕行为地诺孕素/戊酸雌二醇盆腔疼痛地诺孕素/戊酸雌二醇头痛地诺孕素/戊酸雌二醇痛经地诺孕素/戊酸雌二醇
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 米非司酮/米索前列醇Mifepristone/Misoprostol | Tier C — Watch / trade | - |
| 地诺孕素/戊酸雌二醇Dienogest/Estradiol Valerate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(8S,13S,14S)-13-methyl-1,4,6,7,8,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17(2H)-one→prop-1-yne→(8S,13S,14S,17S)-13-methyl-17-(prop-1-yn-1-yl)-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-ol→1,1,1,3,3,3-hexafluoropropan-2-one→(5'R,8'S,10'R,13'S,14'S,17'S)-13'-methyl-17'-(prop-1-yn-1-yl)-1',2',7',8',12',13',14',15',16',17'-decahydro-4'H,6'H-spiro[[1,3]dioxolane-2,3'-[5,10]epoxycyclopenta[a]phenanthren]-17'-ol→(4-(dimethylamino)phenyl)magnesium bromide→(8S,11R,13S,14S,17S)-11-(4-(dimethylamino)phenyl)-13-methyl-17-(prop-1-yn-1-yl)-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-ol
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