CAS 590-93-2

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid

Codes：ACAT-011

Application context (from source-drug indications)

套细胞淋巴瘤阿可替尼慢性淋巴细胞白血病阿可替尼淋巴细胞性白血病阿可替尼

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
阿可替尼Acalabrutinib	Tier A — Act now	2030

Position in synthesis routes (up/downstream chain)

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阿可替尼原研路线steps: 8total yield: 10.5 mg

3-chloropyrazine-2-carbonitrile→(3-chloropyrazin-2-yl)methanamine hydrochloride→((benzyloxy)carbonyl)-L-proline→benzyl (S)-2-(((3-chloropyrazin-2-yl)methyl)carbamoyl)pyrrolidine-1-carboxylate→benzyl (S)-2-(8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate→benzyl (S)-2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate→benzyl (S)-2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate→N-(pyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide→benzyl (S)-2-(8-amino-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate→(S)-4-(8-amino-3-(pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide→4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	2-Butynoic Acid Pharmaceutical Intermediates	询价	询价	询价	—

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