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CAS 60099-09-4
Benzyl imidoformate hydrogen chloride
Codes：Imipenem-013
Application context (from source-drug indications)
细菌性肺炎亚胺西瑞医院获得性肺炎亚胺西瑞传染性疾病亚胺西瑞菌血症亚胺西瑞呼吸机相关性肺炎亚胺西瑞医疗保健相关性肺炎亚胺西瑞
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 亚胺西瑞Cilastatin Sodium/Imipenem/Relebactam | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-Nitrobenzyl (5R,6S)-6-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate→4-Nitrobenzyl (5R,6S)-6-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-3-([2-[(iminomethyl)amino]ethyl]sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate hydrogen chloride→4-Nitrobenzyl (5R,6S)-6-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-3-[(diphenoxyphosphoryl)oxy]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate→2-Mercaptoethylamine hydrochloride→4-Nitrobenzyl (5R,6S)-3-[(2-aminoethyl)sulfanyl]-6-[(1R)-1-[[tert-butyl(dimethyl)silyl]oxy]ethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate hydrogen chloride→2(R)-Acetoxy-3(R)-[O-TBDMS-1(R)-hydroxyethyl]-4-azetidinone→(4-Nitrophenyl)methyl 2-diazo-3-[(trimethylsilyl)oxy]but-3-enoate→4-[3(S)-[1(R)-[tert-Butyl(dimethyl)silyloxy]ethyl]-4-oxoazetidin-2(R)-yl]-2-diazo-3-oxobutyric acid 4-nitrobenzyl ester→Benzyl imidoformate hydrogen chloride
(4-Nitrophenyl)methyl (5R,6S)-3-[(2-aminoethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 1-methylpyrrolidin-2-one hydrogen chloride→(4-Nitrophenyl)methyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-([2-[(iminomethyl)amino]ethyl]sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate hydrogen chloride→Benzyl imidoformate hydrogen chloride
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