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CAS 603983-67-1

(2R)-2-Hydroxy-2-(3-hydroxyphenyl)ethyl 4-methylbenzenesulfonate

Codes:Phenylephrine Hydrochloride-016

Application context (from source-drug indications)

感冒布洛芬/盐酸去氧肾上腺素发热布洛芬/盐酸去氧肾上腺素头痛布洛芬/盐酸去氧肾上腺素

Source drugs (routes using this intermediate)

DrugTierExpiry
布洛芬/盐酸去氧肾上腺素Ibuprofen/Phenylephrine HydrochlorideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

布洛芬/盐酸去氧肾上腺素优化路线steps: 9total yield: /
(3-Hydroxyphenyl)formaldehyde→3-(tert-Butyldimethylsilyloxy)benzaldehyde→Methylene(triphenyl)phosphorane→Methyl(triphenyl)phosphonium iodide→tert-Butyl(dimethyl)(3-vinylphenoxy)silane→(1R)-1-(3-[[tert-Butyl(dimethyl)silyl]oxy]phenyl)ethane-1,2-diol→(2R)-2-(3-[[tert-Butyl(dimethyl)silyl]oxy]phenyl)-2-hydroxyethyl 4-methylbenzenesulfonate→(2R)-2-Hydroxy-2-(3-hydroxyphenyl)ethyl 4-methylbenzenesulfonate→3-[(1R)-1-Hydroxy-2-iodoethyl]phenol→Aminomethane→3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol

Intermediates available on this site

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