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CAS 611-73-4

2-oxo-2-phenylacetic acid

Codes：GLYC-022

Application context (from source-drug indications)

哮喘布地奈德/富马酸福莫特/格隆溴铵慢性阻塞性肺疾病布地奈德/富马酸福莫特/格隆溴铵慢性阻塞性肺疾病马来酸茚达特罗/格隆溴铵

Source drugs (routes using this intermediate)

DrugTierExpiry
布地奈德/富马酸福莫特/格隆溴铵Budesonide/Formoterol fumarate/Glycopyrronium BromideTier B — Position early-
马来酸茚达特罗/格隆溴铵Indacaterol Maleate/Glycopyrronium BromideTier B — Position early-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

布地奈德/富马酸福莫特/格隆溴铵优化路线steps: 4total yield: 3.9 g (Glycopyrronium Bromide)
bromocyclopentane→methyl 2-cyclopentyl-2-hydroxy-2-phenylacetate→2-cyclopentyl-2-hydroxy-2-phenylacetic acid→1-methylpyrrolidin-3-ol→1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate→2-oxo-2-phenylacetic acid
马来酸茚达特罗/格隆溴铵优化路线steps: 4total yield: 3.9 g (Glycopyrronium Bromide)
bromocyclopentane→methyl 2-cyclopentyl-2-hydroxy-2-phenylacetate→2-cyclopentyl-2-hydroxy-2-phenylacetic acid→1-methylpyrrolidin-3-ol→1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate→2-oxo-2-phenylacetic acid

Intermediates available on this site

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