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CAS 618910-81-9

4-(3,4-Dichlorophenyl)-4-phenylbut-3-enoic acid

Codes:Sertraline Hydrochloride-017

Application context (from source-drug indications)

强迫性障碍枸橼酸舍曲林

Source drugs (routes using this intermediate)

DrugTierExpiry
枸橼酸舍曲林Sertraline CitrateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

枸橼酸舍曲林优化路线steps: 10total yield: 65g(Sertraline (Free))
Benzene→3,4-Dichlorobenzoyl chloride→(3,4-Dichlorophenyl)(phenyl)methanone→1,2-Dichloro-4-(1-phenylethenyl)benzene→Butane-1,4-dioic acid diethyl diester→1,4-Diethyl (2Z)-2-[(3,4-dichlorophenyl)(phenyl)methylidene]butanedioate→4-(3,4-Dichlorophenyl)-4-phenylbut-3-enoic acid→4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid→4-(3,4-Dichlorophenyl)-4-phenylbutanoyl chloride→4-(3,4-Dichlorophenyl)-1-tetralone→4-(2,3-Dichlorophenyl)-1-tetralone→1,2-Dichlorobenzene→Aminomethane→N-[(1E)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine→(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine

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