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CAS 618910-83-1

(4R)-4-(3,4-dichlorophenyl)-4-phenylbutanoate; 2-methylpropan-2-aminium

Codes:Sertraline Hydrochloride-080

Application context (from source-drug indications)

强迫性障碍枸橼酸舍曲林

Source drugs (routes using this intermediate)

DrugTierExpiry
枸橼酸舍曲林Sertraline CitrateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

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枸橼酸舍曲林优化路线steps: 6total yield: /
(3,4-Dichlorophenyl)(phenyl)methanone→Butane-1,4-dioic acid diethyl diester→ethyl (3E)-4-(3,4-dichlorophenyl)-4-phenylbut-3-enoate→(2E)-4-(3,4-Dichlorophenyl)-4-phenylbut-2-enoic acid→(3E)-4-(3,4-dichlorophenyl)-4-phenylbut-3-enoate; 2-methylpropan-2-aminium→(4R)-4-(3,4-dichlorophenyl)-4-phenylbutanoate; 2-methylpropan-2-aminium→(4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid→4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one

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