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CAS 623-50-7
Ethyl glycolate
Codes：(II)140605-11-a
Application context (from source-drug indications)
膀胱癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)头颈癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)头颈部鳞状细胞癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)实体瘤多西他赛纳米胶束 (Samyang Biopharmaceuticals)
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 多西他赛纳米胶束 (Samyang Biopharmaceuticals)Docetaxel polymeric micelle (Samyang Biopharmaceuticals) | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylic acid→Ethyl glycolate→ethyl 2-{[(4R,5R)-5-[(2-ethoxy-2-oxoethoxy)carbonyl]-2,2-dimethyl-1,3-dioxolan-4-yl]carbonyloxy}acetate→1,1,1-Trimethyl-N-[(E)-phenylmethylidene]silanamine→4,5-bis(3R,4S)-2-oxo-4-phenylazetidin-3-yl (4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate→4,5-bis(3R,4S)-1-[(tert-butoxy)carbonyl]-2-oxo-4-phenylazetidin-3-yl (4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9,12-bis[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-15-{[(2R,3S)-2-{[(4R,5R)-5-({[(3S)-1-{[(1S,2S,3R,4S,7R,9S,10S,12S,15S)-4-(acetyloxy)-2-(benzoyloxy)-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9,12-bis[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-15-yl]oxy}-3-{[(tert-butoxy)carbonyl]amino}-1-oxo-3-phenylpropan-2-yl]oxy}carbonyl)-2,2-dimethyl-1,3-dioxolan-4-yl]carbonyloxy}-3-{[(tert-butoxy)carbonyl]amino}-3-phenylpropanoyl]oxy}-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9,12-bis[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-15-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9,12-bis[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate
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