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CAS 623-51-8

ethyl 2-mercaptoacetate

Codes:BREX-010

Application context (from source-drug indications)

精神分裂症布瑞哌唑阿尔茨海默病布瑞哌唑躁动布瑞哌唑抑郁布瑞哌唑抑郁症布瑞哌唑重度抑郁症布瑞哌唑

Source drugs (routes using this intermediate)

DrugTierExpiry
布瑞哌唑BrexpiprazoleTier A — Act now2029

Position in synthesis routes (up/downstream chain)

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布瑞哌唑优化路线steps: 5total yield: 1.3 g
2-chloro-6-fluorobenzaldehyde→tert-butyl piperazine-1-carboxylate→tert-butyl 4-(3-chloro-2-formylphenyl)piperazine-1-carboxylate→ethyl 2-mercaptoacetate→tert-butyl 4-(2-(ethoxycarbonyl)benzo[b]thiophen-4-yl)piperazine-1-carboxylate→4-(4-(tert-butoxycarbonyl)piperazin-1-yl)benzo[b]thiophene-2-carboxylic acid→tert-butyl 4-(benzo[b]thiophen-4-yl)piperazine-1-carboxylate

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