CAS 65090-78-0

2-bromo-3-methoxypropanoic acid

Codes：LACO-017

Application context (from source-drug indications)

强直阵挛性癫痫拉考沙胺癫痫拉考沙胺癫痫部分性发作拉考沙胺癫痫发作拉考沙胺

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
拉考沙胺Lacosamide	Tier B — Position early	2028

Position in synthesis routes (up/downstream chain)

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拉考沙胺优化路线steps: 5total yield: /

phenylmethanamine→(R)-2-amino-N-benzyl-3-methoxypropanamide→ethyl 2,3-dibromopropanoate→sodium methanolate→2-bromo-3-methoxypropanoic acid→N-benzyl-2-bromo-3-methoxypropanamide→2-amino-N-benzyl-3-methoxypropanamide→(2S,3S)-2,3-bis(benzoyloxy)succinic acid

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