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CAS 65676-21-3

(2RS)-2-(4-Chlorophenyl)-4-(dimethylamino)-2-(pyridin-2-yl)butanenitrile

Codes:Chlorphenamine Maleate-021

Application context (from source-drug indications)

鼻塞氢溴酸右美沙芬/马来酸氯苯那敏/氯化铵打喷嚏氢溴酸右美沙芬/马来酸氯苯那敏/氯化铵咳嗽氢溴酸右美沙芬/马来酸氯苯那敏/氯化铵感冒对乙酰氨基酚/马来酸氯苯那敏/盐酸甲基麻黄碱/愈创木酚磺酸钾/咖啡因

Source drugs (routes using this intermediate)

DrugTierExpiry
氢溴酸右美沙芬/马来酸氯苯那敏/氯化铵Dextromethorphan Hydrobromide/Chlorphenamine Maleate/Ammonium chlorideTier C — Watch / trade-
对乙酰氨基酚/马来酸氯苯那敏/盐酸甲基麻黄碱/愈创木酚磺酸钾/咖啡因Acetaminophen/Chlorphenamine Maleate/Methylephedrine Hydrochloride/Sulfogaiacol/CaffeineTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

氢溴酸右美沙芬/马来酸氯苯那敏/氯化铵优化路线steps: 5total yield: 64g(Chlorphenamine Maleate (API))
(p-Chlorophenyl)acetonitrile→2-Chloranylpyridine→2-Bromanylpyridine→(4-Chlorophenyl)(pyridin-2-yl)acetonitrile→2-(Dimethylamino)ethyl chloride→1-Chloro-2-dimethylaminoethane hydrochloride→2-(Dimethylamino)ethanol→(2RS)-2-(4-Chlorophenyl)-4-(dimethylamino)-2-(pyridin-2-yl)butanenitrile→1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
对乙酰氨基酚/马来酸氯苯那敏/盐酸甲基麻黄碱/愈创木酚磺酸钾/咖啡因优化路线steps: 5total yield: 64g(Chlorphenamine Maleate (API))
(p-Chlorophenyl)acetonitrile→2-Chloranylpyridine→2-Bromanylpyridine→(4-Chlorophenyl)(pyridin-2-yl)acetonitrile→2-(Dimethylamino)ethyl chloride→1-Chloro-2-dimethylaminoethane hydrochloride→2-(Dimethylamino)ethanol→(2RS)-2-(4-Chlorophenyl)-4-(dimethylamino)-2-(pyridin-2-yl)butanenitrile→1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane

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