CAS 697-73-4

2-(chloromethyl)-1,3-difluorobenzene

Codes：RELU-003

Application context (from source-drug indications)

前列腺癌瑞卢戈利平滑肌瘤瑞卢戈利

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
瑞卢戈利Relugolix	Tier C — Watch / trade	2031

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

瑞卢戈利原研路线steps: 9total yield: /

ethyl 2-amino-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate→ethyl 2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate→2-(chloromethyl)-1,3-difluorobenzene→ethyl 2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate→ethyl 4-(bromomethyl)-2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-5-(4-nitrophenyl)thiophene-3-carboxylate→ethyl 2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-(((2-methoxyethyl)(methyl)amino)methyl)-5-(4-nitrophenyl)thiophene-3-carboxylate→ethyl 5-(4-aminophenyl)-2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-(((2-methoxyethyl)(methyl)amino)methyl)thiophene-3-carboxylate→ethyl 2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-(((2-methoxyethyl)(methyl)amino)methyl)-5-(4-(3-methoxyureido)phenyl)thiophene-3-carboxylate→2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-(((2-methoxyethyl)(methyl)amino)methyl)-5-(4-(3-methoxyureido)phenyl)thiophene-3-carboxylic acid→6-chloropyridazin-3-amine→1-(4-(1-(2,6-difluorobenzyl)-5-(((2-methoxyethyl)(methyl)amino)methyl)-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea→1-chloroethyl carbonochloridate

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-((dimethylamino)methyl)-5-(4-nitrophenyl)thiophene-3-carboxylic acid Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	3-AMINO-6-METHOXYPYRIDAZINE Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	ethyl 2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	2-AcetaMido-4,5-diMethylthiophene-3-carboxylic acid Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	3-Thiophenecarboxylic acid, 2-[[(2,6-difluorophenyl)methyl](propoxycarbonyl)amino]-4-[(dimethylamino)methyl]-5-(4-nitrophenyl)-, ethyl ester Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	3-Thiophenecarboxylic acid,5-(4-aminophenyl)-2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino]-4-[(dimethylamino)methyl]-,ethylester, hydrochloride (1:2) Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	2-[(2,6-Difluorobenzyl)ethoxycarbonylamino]-4-((dimethylamino)methyl)-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester Pharmaceutical Intermediates	询价	询价	询价	—

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