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CAS 709031-39-0
(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide hydrochloride
Codes：SAXA-049
Application context (from source-drug indications)
二型糖尿病达格列净丙二醇一水化物/盐酸沙格列汀
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 达格列净丙二醇一水化物/盐酸沙格列汀Dapagliflozin Propanediol Monohydrate/Saxagliptin Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(tert-butyl) 2-ethyl (S)-2,3-dihydro-1H-pyrrole-1,2-dicarboxylate→tert-butyl (S)-2-carbamoyl-2,3-dihydro-1H-pyrrole-1-carboxylate→tert-butyl (1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate→tert-butyl ((S)-2-((1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)carbamate→tert-butyl ((S)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)carbamate→(S)-2-amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→(S)-2-((3S,5S,7S)-adamantan-1-yl)-2-aminoacetic acid→(S)-2-((tert-butoxycarbonyl)amino)-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide hydrochloride→1-((3r,5r,7r)-adamantan-1-yl)ethanone→2-((3r,5r,7r)-adamantan-1-yl)-2-oxoacetic acid
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