Unibest 优贝德
← Back to patent-cliff list

CAS 72-18-4

(S)-2-amino-3-methylbutanoic acid

Codes：VALS-009

Application context (from source-drug indications)

高血压苯磺酸左旋氨氯地平/缬沙坦原发性高血压苯磺酸左旋氨氯地平/缬沙坦原发性高血压缬沙坦/氨氯地平乳清酸盐原发性高血压缬沙坦/盐酸乐卡地平

Source drugs (routes using this intermediate)

DrugTierExpiry
苯磺酸左旋氨氯地平/缬沙坦Levamlodipine Besylate/ValsartanTier C — Watch / trade-
缬沙坦/氨氯地平乳清酸盐Valsartan/Amlodipine OrotateTier C — Watch / trade-
缬沙坦/盐酸乐卡地平Valsartan/Lercanidipine HydrochlorideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

苯磺酸左旋氨氯地平/缬沙坦优化路线steps: 3total yield: /
2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-carbaldehyde→(S)-2-amino-3-methylbutanoic acid→(S,Z)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methylene)amino)-3-methylbutanoic acid→(S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoic acid
缬沙坦/氨氯地平乳清酸盐优化路线steps: 3total yield: /
2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-carbaldehyde→(S)-2-amino-3-methylbutanoic acid→(S,Z)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methylene)amino)-3-methylbutanoic acid→(S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoic acid
缬沙坦/盐酸乐卡地平优化路线steps: 3total yield: /
2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-carbaldehyde→(S)-2-amino-3-methylbutanoic acid→(S,Z)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methylene)amino)-3-methylbutanoic acid→(S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoic acid

Intermediates available on this site

No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.