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CAS 72235-52-0
(2,4-difluorophenyl)methanamine
Codes：DOLU-010
Application context (from source-drug indications)
HIV感染多替拉韦钠分娩多替拉韦钠结核分枝杆菌感染多替拉韦钠肝炎多替拉韦钠疱疹病毒感染多替拉韦钠肝功能衰退多替拉韦钠
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 多替拉韦钠Dolutegravir Sodium | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-hydroxy-2-methyl-4H-pyran-4-one→3-(benzyloxy)-2-methyl-4H-pyran-4-one→3-(benzyloxy)-2-methylpyridin-4(1H)-one→3-(benzyloxy)-5-bromo-2-methylpyridin-4-ol→methyl 5-(benzyloxy)-4-hydroxy-6-methylnicotinate→methyl 4-acetoxy-5-(benzyloxy)-6-methylnicotinate→4-acetoxy-3-(benzyloxy)-5-(methoxycarbonyl)-2-methylpyridine 1-oxide→methyl 4-acetoxy-6-(acetoxymethyl)-5-(benzyloxy)nicotinate→6-(acetoxymethyl)-5-(benzyloxy)-4-oxo-1,4-dihydropyridine-3-carboxylic acid→(2,4-difluorophenyl)methanamine→5-(benzyloxy)-N-(2,4-difluorobenzyl)-6-(hydroxymethyl)-4-oxo-1,4-dihydropyridine-3-carboxamide→5-(benzyloxy)-N-(2,4-difluorobenzyl)-6-formyl-4-oxo-1,4-dihydropyridine-3-carboxamide→3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid→methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylate→methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylate→3-bromoprop-1-ene→methyl 1-allyl-3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylate→methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-4-oxo-1-(2-oxoethyl)-1,4-dihydropyridine-2-carboxylate→(R)-3-aminobutan-1-ol→(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
(2,4-difluorophenyl)methanamine→dimethyl 1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate→1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid→(R)-3-aminobutan-1-ol (2S,3S)-2,3-dihydroxysuccinate→(4R,12aS)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid→(4R,12aS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
3-hydroxy-2-methyl-4H-pyran-4-one→3-(benzyloxy)-2-methyl-4H-pyran-4-one→(2,4-difluorophenyl)methanamine→(R)-3-aminobutan-1-ol→(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide→3-(benzyloxy)-2-(2-hydroxy-2-phenylethyl)-4H-pyran-4-one→(E)-3-(benzyloxy)-2-styryl-4H-pyran-4-one→3-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid→3-aminopropane-1,2-diol→3-(benzyloxy)-1-(2,3-dihydroxypropyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid→methyl 3-(benzyloxy)-1-(2,3-dihydroxypropyl)-4-oxo-1,4-dihydropyridine-2-carboxylate→methyl 3-(benzyloxy)-1-(2,2-dihydroxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate→(4R,12aS)-7-(benzyloxy)-4-methyl-3,4,12,12a-tetrahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-6,8-dione→(4R,12aS)-7-(benzyloxy)-9-bromo-4-methyl-3,4,12,12a-tetrahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-6,8-dione
(2,4-difluorophenyl)methanamine→(R)-3-aminobutan-1-ol→(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide→methyl 4-chloro-3-oxobutanoate→methyl 4-(benzyloxy)-3-oxobutanoate→(Z)-methyl 4-(benzyloxy)-2-((dimethylamino)methylene)-3-oxobutanoate→dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate→2,2-dimethoxyethanamine→dimethyl 3-(benzyloxy)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate→methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate
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