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CAS 78287-26-0

(S)-4-ethyl-4-hydroxy-11-methyl-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione

Codes: BELOH-018

Application context (from source-drug indications)

Non-small cell lung cancerBelotecan HydrochlorideOvarian cancerBelotecan HydrochlorideSolid tumourBelotecan Hydrochloride

Source drugs (routes using this intermediate)

DrugTierExpiry
Belotecan HydrochlorideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Belotecan HydrochlorideOptimised routesteps: 2total yield: 12.1 g
(S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione→(S)-4-ethyl-4-hydroxy-11-methyl-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione
Belotecan HydrochlorideOptimised routesteps: 2total yield: /
(S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione→(S)-4-ethyl-4-hydroxy-11-methyl-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione→2,4,6,8-tetramethyl-1,3,5,7-tetraoxocane→1,3,5-trioxane

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