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CAS 82717-96-2

N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanineN-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine

Codes：Enalapril-003

Application context (from source-drug indications)

心脏和血管疾病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高血压阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高脂血症阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利心脏病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利原发性高血压马来酸依那普利/叶酸

Source drugs (routes using this intermediate)

DrugTierExpiry
阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利Atorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilTier C — Watch / trade-
马来酸依那普利/叶酸Enalapril Maleate/Folic AcidTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利优化路线steps: 2total yield: 4.2g(Enalapril)
N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine→(-)-L-Proline<-fgf->L-Proline→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline→trans-2-Butenedioic acid
阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利优化路线steps: 4total yield: 4.11g(Enalapril)
N-[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanine hydrochloride→Ethyl (2S)-2-[[(2S)-1-chloro-1-oxopropan-2-yl]amino]-4-phenylbutanoate→Benzyl L-prolinate hydrochloride→Benzyl N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-prolinate→N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine
阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利优化路线steps: 5total yield: 206.58g(Enalapril)
Pyrrolidine→Ethyl (2S)-2-[[(2S)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]amino]-4-phenylbutanoate→Trimethylsilyl 1-(trimethylsilyl)-L-prolinate→Trimethylsilyl N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-prolinate→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline→N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine→(S)-(-)-Proline
阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利优化路线steps: 3total yield: 20.9g(Enalapril)
N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine→(S)-(-)-Proline→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
马来酸依那普利/叶酸优化路线steps: 2total yield: 4.2g(Enalapril)
N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine→(-)-L-Proline<-fgf->L-Proline→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline→trans-2-Butenedioic acid
马来酸依那普利/叶酸优化路线steps: 4total yield: 4.11g(Enalapril)
N-[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanine hydrochloride→Ethyl (2S)-2-[[(2S)-1-chloro-1-oxopropan-2-yl]amino]-4-phenylbutanoate→Benzyl L-prolinate hydrochloride→Benzyl N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-prolinate→N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine
马来酸依那普利/叶酸优化路线steps: 5total yield: 206.58g(Enalapril)
Pyrrolidine→Ethyl (2S)-2-[[(2S)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]amino]-4-phenylbutanoate→Trimethylsilyl 1-(trimethylsilyl)-L-prolinate→Trimethylsilyl N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-prolinate→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline→N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine→(S)-(-)-Proline
马来酸依那普利/叶酸优化路线steps: 3total yield: 20.9g(Enalapril)
N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine→(S)-(-)-Proline→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline

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