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CAS 82753-05-7
3-[Benzyl(dimethyl)silyl]prop-2-yn-1-ol
Codes：Sertraline Hydrochloride-140
Application context (from source-drug indications)
强迫性障碍枸橼酸舍曲林
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 枸橼酸舍曲林Sertraline Citrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(2-Propynyloxy)tetrahydropyran→3-[Benzyl(dimethyl)silyl]prop-2-yn-1-ol→(2E)-3-[Benzyl(dimethyl)silyl]prop-2-en-1-ol→(2E)-3-[Benzyl(dimethyl)silyl]prop-2-en-1-yl methanesulfonate→Pentafluorophenyl phenylacetate→2-Phenylacetic acid→tert-Butyl [(1S,3E)-4-[benzyl(dimethyl)silyl]-1-phenylbut-3-en-1-yl]carbamate→1,2-Dichloro-4-iodobenzene→tert-Butyl [(1S,3E)-4-(3,4-dichlorophenyl)-1-phenylbut-3-en-1-yl]carbamate→N-[(Z)-Phenylmethylidene]carbamic acid tert-butyl ester→Acetaldehyde→N-Boc-3(S)-amino-3-phenylpropanaldehyde→[(3,4-Dichlorophenyl)methyl](triphenyl)phosphanium bromide→Iodomethane→tert-Butyl [(1S,3E)-4-(3,4-dichlorophenyl)-1-phenylbut-3-en-1-yl]methylcarbamate
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