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CAS 83515-96-2
(±)-7-Methyl-1,4-dioxaspiro[4.5]decane-7,8-diol
Codes：(V)101438-57-a,(V)101438-57-b
Application context (from source-drug indications)
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-Methoxy-3-methylbenzene→1-Methoxy-5-methyl-1,4-cyclohexadiene→7-Methyl-1,4-dioxaspiro[4.5]dec-7-ene→3-Methyl-2-cyclohexen-1-one→Chlorido(ethenyl)magnesium→(±)-7-Methyl-1,4-dioxaspiro[4.5]decane-7,8-diol→(-)-(7R,8S)-7-Methyl-1,4-dioxaspiro[4.5]decane-7,8-diol→(7R,8S)-8-(Benzyloxy)-7-methyl-1,4-dioxaspiro[4.5]decan-7-ol→(4S)-4-(Benzyloxy)-3-methylcyclohex-2-en-1-one→[[(3S,4S)-4-(Benzyloxy)-3-ethenyl-3-methylcyclohex-1-en-1-yl]oxy](trimethyl)silane→(2R,3S,4S)-4-(Benzyloxy)-2-(hydroxymethyl)-3-methyl-3-vinylcyclohexanone→(2S,3S,4S)-4-(Benzyloxy)-3-ethenyl-2-(hydroxymethyl)-3-methylcyclohexanone
(±)-7-Methyl-1,4-dioxaspiro[4.5]decane-7,8-diol→(4S)-4-(Benzyloxy)-3-methylcyclohex-2-en-1-one→(+)-(7S,8R)-7-Hydroxy-7-methyl-1,4-dioxaspiro[4.5]decan-8-yl dodecanoate→(+)-(7S,8R)-7-Methyl-1,4-dioxaspiro[4.5]decane-7,8-diol→(7S)-7-Hydroxy-7-methyl-1,4-dioxaspiro[4.5]decan-8-one→(7S,8S)-7-Methyl-1,4-dioxaspiro[4.5]decane-7,8-diol→(7S,8S)-8-(Benzyloxy)-7-methyl-1,4-dioxaspiro[4.5]decan-7-ol
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