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CAS 84793-24-8
Ethyl (2S)-2-[(4S)-4-methyl-2,5-dioxo-1,3-oxazolidin-3-yl]-4-phenylbutanoate
Codes：Ramipril-031、Ramipril-041
Application context (from source-drug indications)
高胆固醇血症阿托伐他汀钙/雷米普利高血压阿托伐他汀钙/雷米普利
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 阿托伐他汀钙/雷米普利Atorvastatin Calcium Hydrate/Ramipril | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate→Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride→Ethyl (2S)-2-[(4S)-4-methyl-2,5-dioxo-1,3-oxazolidin-3-yl]-4-phenylbutanoate→(2S,3aS,6aS)-1-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]perhydrocyclopenta[b]pyrrole-2-carboxylic acid
methyl 3-chloro-2-(2-phenylacetamido)propanoate→1-(1-Cyclopentenyl)pyrrolidine→methyl 3-(2-oxocyclopentyl)-2-(2-phenylacetamido)propanoate→3-(2-oxocyclopentyl)-2-(2-phenylacetamido)propanoic acid→3-(2-Oxocyclopentyl)-L-alanine→(2S)-2,3,3a,4,5,6-Hexahydrocyclopenta[b]pyrrole-2-carboxylic acid→(2S,3aS,6aS)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid→1-Phenylmethanol→N'-[(1E)-{6-[(2S)-2-hydroxypropyl]-2H-1,3-benzodioxol-5-yl}(4-nitrophenyl)methylidene]acetohydrazide→Ethyl (2S)-2-[(4S)-4-methyl-2,5-dioxo-1,3-oxazolidin-3-yl]-4-phenylbutanoate→(2S,3aS,6aS)-1-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]perhydrocyclopenta[b]pyrrole-2-carboxylic acid
N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine→Carbonochloridic acid ethyl ester→ethyl (2S)-2-[(ethoxycarbonyl)[(2S)-1-[(ethoxycarbonyl)oxy]-1-oxopropan-2-yl]amino]-4-phenylbutanoate→Ethyl (2S)-2-[(4S)-4-methyl-2,5-dioxo-1,3-oxazolidin-3-yl]-4-phenylbutanoate→Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate→(2S,3aS,6aS)-1-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]perhydrocyclopenta[b]pyrrole-2-carboxylic acid
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