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CAS 865999-65-1
(S)-2-(2,2,2-trifluoroacetamido)-2-((1r,3R,5R,7S)-3-(2,2,2-trifluoroacetoxy)adamantan-1-yl)acetic acid
Codes：SAXA-044
Application context (from source-drug indications)
二型糖尿病达格列净丙二醇一水化物/盐酸沙格列汀
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 达格列净丙二醇一水化物/盐酸沙格列汀Dapagliflozin Propanediol Monohydrate/Saxagliptin Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-2-amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid hydrochloride→(S)-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-(2,2,2-trifluoroacetamido)acetic acid→(S)-2-(2,2,2-trifluoroacetamido)-2-((1r,3R,5R,7S)-3-(2,2,2-trifluoroacetoxy)adamantan-1-yl)acetic acid→(1R,3r,5R,7S)-3-((S)-2-chloro-2-oxo-1-(2,2,2-trifluoroacetamido)ethyl)adamantan-1-yl 2,2,2-trifluoroacetate→(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride→(1R,3r,5R,7S)-3-((S)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxo-1-(2,2,2-trifluoroacetamido)ethyl)adamantan-1-yl 2,2,2-trifluoroacetate→N-((S)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)-2,2,2-trifluoroacetamide
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