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CAS 871123-99-8

(3R)-3-Benzyl-L-aspartic acid

Codes：Enalapril-072

Application context (from source-drug indications)

心脏和血管疾病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高血压阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高脂血症阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利心脏病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利原发性高血压马来酸依那普利/叶酸

Source drugs (routes using this intermediate)

DrugTierExpiry
阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利Atorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilTier C — Watch / trade-
马来酸依那普利/叶酸Enalapril Maleate/Folic AcidTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利优化路线steps: 5total yield: 3.9g(Enalapril-073)
(S)-Aminobutanedioic acid→Dimethyl L-aspartate hydrogen chloride→Dimethyl N-(triphenylmethyl)-L-aspartate→1-(Bromomethyl)benzene→Dimethyl 3-benzyl-N-(triphenylmethyl)-L-aspartate→(3R)-3-Benzyl-L-aspartic acid→2(S)-Amino-4-phenylbutanoic acid
马来酸依那普利/叶酸优化路线steps: 5total yield: 3.9g(Enalapril-073)
(S)-Aminobutanedioic acid→Dimethyl L-aspartate hydrogen chloride→Dimethyl N-(triphenylmethyl)-L-aspartate→1-(Bromomethyl)benzene→Dimethyl 3-benzyl-N-(triphenylmethyl)-L-aspartate→(3R)-3-Benzyl-L-aspartic acid→2(S)-Amino-4-phenylbutanoic acid

Intermediates available on this site

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