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CAS 90003-74-0

2,2-Dichloro-N-(5-chloro-2,4-disulfamoylphenyl)acetamide

Codes:Trichlormethiazide-005

Application context (from source-drug indications)

高血压厄贝沙坦/三氯噻嗪

Source drugs (routes using this intermediate)

DrugTierExpiry
厄贝沙坦/三氯噻嗪Irbesartan/TrichlormethiazideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

厄贝沙坦/三氯噻嗪优化路线steps: 8total yield: /
4-Amino-6-chlorobenzene-1,3-disulfonyl dichloride→2,2-Dichloroacetic acid chloride→Dichloroacetic anhydride→4-Chloro-6-(2,2-dichloroacetamido)benzene-1,3-disulfonyl dichloride→2,2-Dichloro-N-(5-chloro-2,4-disulfamoylphenyl)acetamide→6-Chloro-3-(dichloromethyl)-1,1-dioxo-1,2-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide→2,2-Dichloroacetonitrile→Ethyl 2,2-dichloroethanimidoate hydrochloride→2,2-Dichloro-1,1,1-triethoxyethane→4-Amino-6-chlorobenzene-1,3-disulfonamide→Dichloroacetaldehyde→1,1-Dichloro-2,2-diethoxyethane

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