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CAS 909567-52-8

N,N'-Bis[(2S)-1-[[tert-butyl(dimethyl)silyl]oxy]butan-2-yl]ethanediamide

Codes:Ethambutol Hydrochloride-011

Application context (from source-drug indications)

结核分枝杆菌感染盐酸乙胺丁醇/利福平/异烟肼肺结核盐酸乙胺丁醇

Source drugs (routes using this intermediate)

DrugTierExpiry
Ethambutol Hydrochloride/Rifampicin/IsoniazidEthambutol Hydrochloride/Rifampicin/IsoniazidTier C — Watch / trade-
Ethambutol HydrochlorideEthambutol HydrochlorideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Ethambutol Hydrochloride/Rifampicin/Isoniazid优化路线steps: 6total yield: /
(R)-1,2-Butanediol→O-TBDMS-1,2(R)-butanediol→(2S)-1-[[tert-Butyl(dimethyl)silyl]oxy]butan-2-yl methanesulfonate→[[(2S)-2-Azidobutyl]oxy](tert-butyl)dimethylsilane→(2S)-1-[[tert-Butyl(dimethyl)silyl]oxy]butan-2-amine→Oxalyl dichloride→N,N'-Bis[(2S)-1-[[tert-butyl(dimethyl)silyl]oxy]butan-2-yl]ethanediamide
Ethambutol Hydrochloride优化路线steps: 6total yield: /
(R)-1,2-Butanediol→O-TBDMS-1,2(R)-butanediol→(2S)-1-[[tert-Butyl(dimethyl)silyl]oxy]butan-2-yl methanesulfonate→[[(2S)-2-Azidobutyl]oxy](tert-butyl)dimethylsilane→(2S)-1-[[tert-Butyl(dimethyl)silyl]oxy]butan-2-amine→Oxalyl dichloride→N,N'-Bis[(2S)-1-[[tert-butyl(dimethyl)silyl]oxy]butan-2-yl]ethanediamide

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