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CAS 911314-60-8
4'-(bromomethyl)-[1,1'-biphenyl]-2-carbaldehyde
Codes：AZILS-012
Application context (from source-drug indications)
高血压阿齐沙坦原发性高血压阿齐沙坦二型糖尿病阿齐沙坦肥胖症阿齐沙坦糖尿病阿齐沙坦
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 阿齐沙坦Azilsartan | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
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methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbaldehyde→methyl 2-ethoxy-1-((2'-formyl-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→methyl (E)-2-ethoxy-1-((2'-((hydroxyimino)methyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→methyl (Z)-1-((2'-(chloro(hydroxyimino)methyl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
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