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CAS 912356-08-2
(3aS,12bS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
Codes：ASEN-025
Application context (from source-drug indications)
精神分裂症马来酸阿塞那平躁狂症马来酸阿塞那平I 型双相情感障碍马来酸阿塞那平结巴马来酸阿塞那平偏执型精神分裂症马来酸阿塞那平青春型精神分裂症马来酸阿塞那平
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 马来酸阿塞那平Asenapine Maleate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
ethyl 4-(piperazin-1-yl)benzoate→(E)-1-bromo-2-(2-nitrovinyl)benzene→methyl 2-(5-chloro-2-methoxyphenyl)acetate→methyl 3-(2-bromophenyl)-2-(5-chloro-2-methoxyphenyl)-4-nitrobutanoate→4-(2-bromophenyl)-3-(5-chloro-2-methoxyphenyl)pyrrolidin-2-one→4-(2-bromophenyl)-3-(5-chloro-2-methoxyphenyl)-1-methylpyrrolidin-2-one→3-(2-bromophenyl)-2-(5-chloro-2-methoxyphenyl)-4-(methylamino)butanoic acid→(3S,4S)-4-(2-bromophenyl)-3-(5-chloro-2-methoxyphenyl)-1-methylpyrrolidin-2-one→(3S,4S)-4-(2-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1-methylpyrrolidin-2-one→(3aS,12bS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
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