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CAS 927887-20-5
(E)-2-(2-isopropyl-4-methoxyphenoxy)-3-(phenylamino)acrylonitrile
Codes: GEFAP-006
Application context (from source-drug indications)
CoughGefapixant Citrate间质性膀胱炎Gefapixant CitratePainGefapixant CitrateEndometriosisGefapixant CitrateObstructive sleep apnoea syndromeGefapixant CitrateRenal impairmentGefapixant Citrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Gefapixant Citrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(2-hydroxy-5-methoxyphenyl)ethanone→2-isopropyl-4-methoxyphenol→2-(2-isopropyl-4-methoxyphenoxy)acetonitrile→1-tert-butoxy-N,N,N',N'-tetramethylmethanediamine→3,3-bis(dimethylamino)-2-(2-isopropyl-4-methoxyphenoxy)propanenitrile→(E)-2-(2-isopropyl-4-methoxyphenoxy)-3-(phenylamino)acrylonitrile→5-(2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine→5-((2,4-diaminopyrimidin-5-yl)oxy)-4-isopropyl-2-methoxybenzenesulfonic acid→5-((2,4-diaminopyrimidin-5-yl)oxy)-4-isopropyl-2-methoxybenzenesulfonyl chloride→5-((2,4-diaminopyrimidin-5-yl)oxy)-4-isopropyl-2-methoxybenzenesulfonamide compound with tetrahydrothiophene 1,1-dioxide (1:1)
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