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CAS 99-90-1
1-Acetyl-4-bromobenzene
Codes: Emitasvir Phosphate-011
Application context (from source-drug indications)
Hepatitis CEmitasvir PhosphateRenal impairmentEmitasvir PhosphateHepatic function declineEmitasvir PhosphateChronic hepatitis CEmitasvir Phosphate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Emitasvir Phosphate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
N-Boc-L-proline→tert-Butyl (2S)-2-[4-(4-[(1S,4R)-8-[(trifluoromethanesulfonyl)oxy]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate→1-Acetyl-4-bromobenzene→4'-Bromophenacyl bromide→2-[2-(4-Bromophenyl)-2-oxoethyl] 1-tert-butyl (2S)-pyrrolidine-1,2-dicarboxylate→(S)-tert-Butyl 2-(5-(4-bromophenyl)-1h-imidazol-2-yl)pyrrolidine-1-carboxylate→tert-Butyl (2S)-2-[4-[4-(3,3,4,4-tetramethylborolan-1-yl)phenyl]-1H-imidazol-2-yl]pyrrolidine-1-carboxylate→1,2,3,4-Tetrahydro-1,4-methanonaphthalene-5,8-diyl bis(trifluoromethanesulfonate)→tert-Butyl (2S)-2-[4-(4-[8-[(trifluoromethanesulfonyl)oxy]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate→Quinone→Cyclopenta-1,3-diene→Tricyclo[6.2.1.0,2,7]undeca-4,9-diene-3,6-dione→1,4-Dihydro-1,4-methanonaphthalene-5,8-diol→1,2,3,4-Tetrahydro-1,4-methanonaphthalene-5,8-diol
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