自身免疫 / 炎症中间体目录36 个中间体品种 · 覆盖 5 个靶点 API

类风湿、银屑病、特应性皮炎、炎症性肠病

类目归属依据靶点 API 的主适应症（显式归属表 + 品种目录直连），未收录靶点如实归「未分类」，不作文本猜测。

代谢 / 内分泌心血管 / 肾脏肿瘤 / 血液抗感染自身免疫 / 炎症神经 / 精神消化 / 肝病呼吸泌尿 / 女性健康眼科皮肤科麻醉 / 镇痛抗过敏动物保健未分类

本类品种

中间体名称	CAS 号	对应药物
Ethyl (2R,3S)-2-(4-(cyclopentylamino)phenyl)piperidine-3-carboxylate bis((2R,3R)-2,3-bis((4-methylbenzoyl)oxy)succinate)	1893415-79-6	AVACOPAN
(2R,3S)-2-(4-(cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)piperidine-3-carboxylic acid	1346623-11-7	AVACOPAN
tert-butyl 3-(4-nitrophenyl)-3-oxopropanoate	142550-25-2	AVACOPAN
Ethyl 4-nitrobenzoylacetate	838-57-3	AVACOPAN
Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2R,3R)-, compd. with ethyl (2R,3S)-2-[4-[[(1,1-dimethylethoxy)carbonyl]amino]phenyl]-3-piperidinecarboxylate (1:1)	1357259-88-1	AVACOPAN
Ethyl 4,6-dichloropyrridazine-3-carboxylate	679406-03-2	Deucravacitinib
Methyl 4,6-dichloropyridazine-3-carboxylate	372118-01-9	Deucravacitinib
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline	1609394-10-6	Deucravacitinib
4,6-dichloro-N-trideuteromethylpyridazine-3 -carboxamide	1609393-89-6	Deucravacitinib
4,6-dihydroxypyridazine-3-carboxylicacid	1442437-21-9	Deucravacitinib
ethyl 4,6-dihydroxypyridazine-3-carboxylate	1352925-63-3	Deucravacitinib
Methyl 4,6-dihydroxypyridazine-3-carboxylate	372118-00-8	Deucravacitinib
4,6-Dichloro-3-pyridazinecarboxylic acid, lithium salt	2245238-80-4	Deucravacitinib
Lithium 4,6-Dichloropyridazine-3-carboxylate Hydrate	2245111-15-1	Deucravacitinib
tert-Butyl5-methoxy-7-methyl-1H-indole-1-carboxylate	1387445-50-2	Ipatacopan Hydrochloride
tert-Butyl 4-formyl-5-methoxy-7-methyl-1Hindole-1-carboxylate	1481631-51-9	Ipatacopan Hydrochloride
tert-butyl 4-formyl-5-hydroxy-7-methyl-1Hindole-1-carboxylate	2408761-23-7	Ipatacopan Hydrochloride
1H-Indole-1-carboxylic acid, 5-hydroxy-7-methyl-, 1,1-dimethylethyl ester	2408761-22-6	Ipatacopan Hydrochloride
methyl4-((2S,4S)-4-ethoxypiperidin-2-yl)benzoate	1644667-61-7	Ipatacopan Hydrochloride
Benzoic acid, 4-[(2R,4R)-4-ethoxy-2-piperidinyl]-, methyl ester, rel-	1644667-62-8	Ipatacopan Hydrochloride
2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine	74901-69-2	Tolebrutinib hydrochloride
(1-aminocyclobutyl)methanol hydrochloride	1392213-15-8	Tolebrutinib hydrochloride
tert-butyl (R)-3-((2-chloro-3-nitropyridin-4-yl)amino)piperidine-1-carboxylate	1971921-29-5	Tolebrutinib hydrochloride
tert-butyl (R)-3-((3-amino-2-chloropyridin-4-yl)amino)piperidine-1-carboxylate	3024285-18-2	Tolebrutinib hydrochloride
tert-butyl (R)-3-((2-(bis(4-methoxybenzyl)amino)-3-nitropyridin-4-yl)amino)piperidine-1-carboxylate	2054950-46-6	Tolebrutinib hydrochloride
tert-butyl (R)-3-(4-[bis[(4-methoxyphenyl)methyl]amino]-2-oxo-3-(4-phenoxyphenyl)-1H,2H,3H-imidazo[4,5-c]pyridin-1-yl)piperidine-1-carboxylate	2054950-51-3	Tolebrutinib hydrochloride
(R)-4-amino-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one	1971921-35-3	Tolebrutinib hydrochloride
(R)-4-amino-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one oxalate	2796185-24-3	Tolebrutinib hydrochloride
tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate	1201187-44-1	Upadacitinib
(3R,4S)-3-(2-Bromoacetyl)-4-ethyl-1-pyrrolidinecarboxylic acid phenylmethyl ester	1428243-26-8	Upadacitinib
N-[5-[(4-Methylphenyl)sulfonyl]-5H-pyrrolo[2,3-b]pyrazin-2-yl]carbamic acid ethyl ester	1869118-24-0	Upadacitinib
N-Tosyl-5-bromo-4,7-diazaindole	1201186-54-0	Upadacitinib
1-[(benzyloxy)carbonyl]-4-ethyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid	1869118-25-1	Upadacitinib
(3R,4S)-1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid	1428243-24-6	Upadacitinib
8-((3R,4S)-4-ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine	1428243-28-0	Upadacitinib
5-Bromo-4,7-diazaindole	875781-43-4	Upadacitinib

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