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Imarikiren hydrochloride
Tier C · 观察 / 贸易Imarikiren hydrochloride
武田药品工业株式会社
原研
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首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：REN
适应症（已批准）：高血压、糖尿病肾病、肝功能衰退、肾功能不全
各地区研发/上市状态
美国
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欧盟
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中国
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日本
临床二期
2018-01-01
合成路线与中间体2 routes
原研路线 × 1优化路线（非专利）× 0工艺路线 × 1
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 14 · 总收率 2.6 g
IMARIK-001499-81-0IMARIK-0024591-55-3IMARIK-003595555-70-7IMARIK-004191544-71-5IMARIK-005534572-28-6IMARIK-006—IMARIK-0071145747-61-0IMARIK-008191544-79-3IMARIK-0091145745-30-7IMARIK-0103584-65-4IMARIK-0111202261-55-9IMARIK-012823226-17-1IMARIK-0131202261-60-6IMARIK-0141202261-65-1IMARIK-0151202261-27-5Imarikiren1202265-63-1Imarikiren Hydrochloride1202269-24-6API · Imarikiren hydrochloride
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| IMARIK-001 | 499-81-0 | pyridine-3,5-dicarboxylic acid |
| IMARIK-002 | 4591-55-3 | dimethyl pyridine-3,5-dicarboxylate |
| IMARIK-003 | 595555-70-7 | 1-(tert-butyl) 3,5-dimethyl piperidine-1,3,5-tricarboxylate |
| IMARIK-004 | 191544-71-5 | 1-(tert-butoxycarbonyl)-5-(methoxycarbonyl)piperidine-3-carboxylic acid |
| IMARIK-005 | 534572-28-6 | (3S,5R)-1-(tert-butoxycarbonyl)-5-(methoxycarbonyl)piperidine-3-carboxylic acid |
| IMARIK-006 | - | 1-(tert-butyl) 3-methyl (3R,5S)-5-isocyanatopiperidine-1,3-dicarboxylate |
| IMARIK-007 | 1145747-61-0 | 1-(tert-butyl) 3-methyl (3R,5S)-5-(((benzyloxy)carbonyl)amino)piperidine-1,3-dicarboxylate |
| IMARIK-008 | 191544-79-3 | 1-(tert-butyl) 3-methyl (3R,5S)-5-aminopiperidine-1,3-dicarboxylate |
| IMARIK-009 | 1145745-30-7 | 1-(tert-butyl) 3-methyl (3R,5S)-5-(isobutylamino)piperidine-1,3-dicarboxylate |
| IMARIK-010 | 3584-65-4 | 2-(trichloromethyl)-1H-benzo[d]imidazole |
| IMARIK-011 | 1202261-55-9 | 1-(tert-butyl) 3-methyl (3R,5S)-5-(N-isobutyl-1H-benzo[d]imidazole-2-carboxamido)piperidine-1,3-dicarboxylate |
| IMARIK-012 | 823226-17-1 | 4-methoxybutyl methanesulfonate |
| IMARIK-013 | 1202261-60-6 | 1-(tert-butyl) 3-methyl (3R,5S)-5-(N-isobutyl-1-(4-methoxybutyl)-1H-benzo[d]imidazole-2-carboxamido)piperidine-1,3-dicarboxylate |
| IMARIK-014 | 1202261-65-1 | (3R,5S)-1-(tert-butoxycarbonyl)-5-(N-isobutyl-1-(4-methoxybutyl)-1H-benzo[d]imidazole-2-carboxamido)piperidine-3-carboxylic acid |
| IMARIK-015 | 1202261-27-5 | tert-butyl (3S,5R)-3-(N-isobutyl-1-(4-methoxybutyl)-1H-benzo[d]imidazole-2-carboxamido)-5-(morpholine-4-carbonyl)piperidine-1-carboxylate |
| Imarikiren | 1202265-63-1 | N-isobutyl-1-(4-methoxybutyl)-N-((3S,5R)-5-(morpholine-4-carbonyl)piperidin-3-yl)-1H-benzo[d]imidazole-2-carboxamide |
| Imarikiren Hydrochloride | 1202269-24-6 | N-isobutyl-1-(4-methoxybutyl)-N-((3S,5R)-5-(morpholine-4-carbonyl)piperidin-3-yl)-1H-benzo[d]imidazole-2-carboxamide hydrochloride |
工艺Route 2步骤 16 · 总收率 16.446 kg
IMARIK-001499-81-0IMARIK-0024591-55-3IMARIK-005534572-28-6IMARIK-006—IMARIK-0071145747-61-0IMARIK-0151202261-27-5IMARIK-016920297-39-8IMARIK-017—IMARIK-0181352612-42-0IMARIK-0191145747-62-1IMARIK-0201145747-63-2IMARIK-0211352612-43-1IMARIK-0221202269-25-7IMARIK-02388-74-4IMARIK-02417913-18-7IMARIK-0251248616-01-4IMARIK-0261202261-23-1IMARIK-0272533-69-9Imarikiren1202265-63-1Imarikiren Hydrochloride1202269-24-6API · Imarikiren hydrochloride
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| IMARIK-001 | 499-81-0 | pyridine-3,5-dicarboxylic acid |
| IMARIK-002 | 4591-55-3 | dimethyl pyridine-3,5-dicarboxylate |
| IMARIK-005 | 534572-28-6 | (3S,5R)-1-(tert-butoxycarbonyl)-5-(methoxycarbonyl)piperidine-3-carboxylic acid |
| IMARIK-006 | - | 1-(tert-butyl) 3-methyl (3R,5S)-5-isocyanatopiperidine-1,3-dicarboxylate |
| IMARIK-007 | 1145747-61-0 | 1-(tert-butyl) 3-methyl (3R,5S)-5-(((benzyloxy)carbonyl)amino)piperidine-1,3-dicarboxylate |
| IMARIK-015 | 1202261-27-5 | tert-butyl (3S,5R)-3-(N-isobutyl-1-(4-methoxybutyl)-1H-benzo[d]imidazole-2-carboxamido)-5-(morpholine-4-carbonyl)piperidine-1-carboxylate |
| IMARIK-016 | 920297-39-8 | 1-(tert-butoxycarbonyl)piperidine-3,5-dicarboxylic acid |
| IMARIK-017 | - | tert-butyl (1S,5S)-2,4-dioxo-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate |
| IMARIK-018 | 1352612-42-0 | (R)-1-phenylethan-1-amine (3S,5R)-1-(tert-butoxycarbonyl)-5-(methoxycarbonyl)piperidine-3-carboxylate |
| IMARIK-019 | 1145747-62-1 | (3R,5S)-5-(((benzyloxy)carbonyl)amino)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid |
| IMARIK-020 | 1145747-63-2 | tert-butyl (3S,5R)-3-(((benzyloxy)carbonyl)amino)-5-(morpholine-4-carbonyl)piperidine-1-carboxylate |
| IMARIK-021 | 1352612-43-1 | tert-butyl (3S,5R)-3-(isobutylamino)-5-(morpholine-4-carbonyl)piperidine-1-carboxylate succinate |
| IMARIK-022 | 1202269-25-7 | 1-(4-methoxybutyl)-2-(trichloromethyl)-1H-benzo[d]imidazole |
| IMARIK-023 | 88-74-4 | 2-nitroaniline |
| IMARIK-024 | 17913-18-7 | 1-chloro-4-methoxybutane |
| IMARIK-025 | 1248616-01-4 | N-(4-methoxybutyl)-2-nitroaniline |
| IMARIK-026 | 1202261-23-1 | N1-(4-methoxybutyl)benzene-1,2-diamine |
| IMARIK-027 | 2533-69-9 | methyl 2,2,2-trichloroacetimidate |
| Imarikiren | 1202265-63-1 | N-isobutyl-1-(4-methoxybutyl)-N-((3S,5R)-5-(morpholine-4-carbonyl)piperidin-3-yl)-1H-benzo[d]imidazole-2-carboxamide |
| Imarikiren Hydrochloride | 1202269-24-6 | N-isobutyl-1-(4-methoxybutyl)-N-((3S,5R)-5-(morpholine-4-carbonyl)piperidin-3-yl)-1H-benzo[d]imidazole-2-carboxamide hydrochloride |
常见问题（FAQ）
Imarikiren hydrochloride的适应症有哪些？
已批准的适应症包括：高血压、糖尿病肾病、肝功能衰退、肾功能不全。
Imarikiren hydrochloride的专利什么时候到期？
Imarikiren hydrochloride的专利到期年暂无公开口径，本页会在数据管道核实后更新。
Imarikiren hydrochloride有几条合成路线？
本站收录 2 条合成路线，最短路线 14 步、总收率 2.6 g。每条路线的中间体均带登记编号与 CAS 号。
Imarikiren hydrochloride的关键中间体在哪里可以采购？
Imarikiren hydrochloride路线中的中间体均已建立 CAS 档案，可直接按 CAS 发起询价，需求会进入供应网络撮合池。
如何获取Imarikiren hydrochloride中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-09