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Censavudine
Tier C · 观察 / 贸易Censavudine
耶鲁大学
原研
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首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：HIV-1 RT
适应症（已批准）：进行性核上性麻痹、额颞痴呆、肌萎缩性侧索硬化、Aicardi综合征、HIV感染
各地区研发/上市状态
美国
临床二期
2011-02-01
欧盟
临床二期
2011-02-01
中国
-
日本
-
合成路线与中间体4 routes
原研路线 × 1优化路线（非专利）× 3工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 8 · 总收率 275 mg
CENSA-0011463-10-1CENSA-0021631050-03-7CENSA-00314002-51-8CENSA-0041631050-04-8CENSA-0051631050-05-9CENSA-0061631050-06-0CENSA-0071631050-07-1CENSA-0081631050-08-2CENSA-0091631050-09-3Censavudine634907-30-5API · Censavudine
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| CENSA-001 | 1463-10-1 | 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
| CENSA-002 | 1631050-03-7 | 1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2-methyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
| CENSA-003 | 14002-51-8 | [1,1'-biphenyl]-4-carbonyl chloride |
| CENSA-004 | 1631050-04-8 | ((3aR,4R,6R,6aR)-2-methyl-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl [1,1'-biphenyl]-4-carboxylate |
| CENSA-005 | 1631050-05-9 | ((2R,3R,4R,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(vinyloxy)tetrahydrofuran-2-yl)methyl [1,1'-biphenyl]-4-carboxylate |
| CENSA-006 | 1631050-06-0 | ((2R,3S,4S,5R)-3-iodo-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(vinyloxy)tetrahydrofuran-2-yl)methyl [1,1'-biphenyl]-4-carboxylate |
| CENSA-007 | 1631050-07-1 | ((4R,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(vinyloxy)-4,5-dihydrofuran-2-yl)methyl [1,1'-biphenyl]-4-carboxylate |
| CENSA-008 | 1631050-08-2 | ((2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(2-oxoethyl)-2,5-dihydrofuran-2-yl)methyl [1,1'-biphenyl]-4-carboxylate |
| CENSA-009 | 1631050-09-3 | ((2R,5R)-2-ethynyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl [1,1'-biphenyl]-4-carboxylate |
| Censavudine | 634907-30-5 | 1-((2R,5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
优化Route 2步骤 8 · 总收率 /
CENSA-01098-00-0CENSA-01162644-49-9CENSA-012188670-22-6CENSA-0131170661-01-4CENSA-0141170661-03-6CENSA-0151170661-04-7CENSA-01665-71-4CENSA-0171170661-05-8CENSA-018—Censavudine634907-30-5API · Censavudine
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| CENSA-010 | 98-00-0 | furan-2-ylmethanol |
| CENSA-011 | 62644-49-9 | 5-oxo-5,6-dihydro-2H-pyran-2-yl acetate |
| CENSA-012 | 188670-22-6 | (S)-5-oxo-5,6-dihydro-2H-pyran-2-yl acetate |
| CENSA-013 | 1170661-01-4 | (2S,5S)-5-hydroxy-5-((trimethylsilyl)ethynyl)-5,6-dihydro-2H-pyran-2-yl acetate |
| CENSA-014 | 1170661-03-6 | (5R)-5-(hydroxymethyl)-5-((trimethylsilyl)ethynyl)-2,5-dihydrofuran-2-ol |
| CENSA-015 | 1170661-04-7 | ((2R)-5-acetoxy-2-((trimethylsilyl)ethynyl)-2,5-dihydrofuran-2-yl)methyl acetate |
| CENSA-016 | 65-71-4 | 5-methylpyrimidine-2,4(1H,3H)-dione |
| CENSA-017 | 1170661-05-8 | ((2R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-((trimethylsilyl)ethynyl)-2,5-dihydrofuran-2-yl)methyl acetate |
| CENSA-018 | - | 1-((5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
| Censavudine | 634907-30-5 | 1-((2R,5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
优化Route 3步骤 13 · 总收率 0.26 g
CENSA-01665-71-4CENSA-019108-21-4CENSA-020107-02-8CENSA-021122763-66-0CENSA-022943856-40-4CENSA-023943856-51-7CENSA-024943856-41-5CENSA-025943856-42-6CENSA-0264301-14-8CENSA-027—CENSA-028943856-44-8CENSA-029943856-45-9CENSA-030—CENSA-031221272-62-4CENSA-032943856-52-8CENSA-033943856-49-3Censavudine634907-30-5API · Censavudine
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| CENSA-016 | 65-71-4 | 5-methylpyrimidine-2,4(1H,3H)-dione |
| CENSA-019 | 108-21-4在售 | isopropyl acetate |
| CENSA-020 | 107-02-8 | acrylaldehyde |
| CENSA-021 | 122763-66-0 | isopropyl 3-hydroxypent-4-enoate |
| CENSA-022 | 943856-40-4 | isopropyl 3-(methoxymethoxy)pent-4-enoate |
| CENSA-023 | 943856-51-7 | isopropyl 4,5-dihydroxy-3-(methoxymethoxy)pentanoate |
| CENSA-024 | 943856-41-5 | isopropyl 5-((tert-butyldimethylsilyl)oxy)-4-hydroxy-3-(methoxymethoxy)pentanoate |
| CENSA-025 | 943856-42-6 | isopropyl 5-((tert-butyldimethylsilyl)oxy)-3-(methoxymethoxy)-4-oxopentanoate |
| CENSA-026 | 4301-14-8 | ethynylmagnesium bromide |
| CENSA-027 | - | isopropyl (3S,4R)-4-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxy-3-(methoxymethoxy)hex-5-ynoate |
| CENSA-028 | 943856-44-8 | (4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-4-(methoxymethoxy)tetrahydrofuran-2-ol |
| CENSA-029 | 943856-45-9 | (4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-4-(methoxymethoxy)tetrahydrofuran-2-yl acetate |
| CENSA-030 | - | 1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-4-(methoxymethoxy)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
| CENSA-031 | 221272-62-4 | 1-((2R,4S,5R)-5-ethynyl-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
| CENSA-032 | 943856-52-8 | 1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
| CENSA-033 | 943856-49-3 | (2R,3S,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-2-ethynyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl methanesulfonate |
| Censavudine | 634907-30-5 | 1-((2R,5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
优化Route 4步骤 9 · 总收率 /
CENSA-03435436-57-8CENSA-035582302-77-0CENSA-036106-45-6CENSA-0371498325-15-7CENSA-03854655-07-1CENSA-0391498325-08-8CENSA-0401498325-19-1CENSA-0411498325-23-7CENSA-0421498325-10-2CENSA-0437288-28-0CENSA-0441498325-12-4CENSA-045744217-17-2Censavudine634907-30-5API · Censavudine
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| CENSA-034 | 35436-57-8 | 6-hydroxy-2H-pyran-3(6H)-one |
| CENSA-035 | 582302-77-0 | (S)-5-oxo-5,6-dihydro-2H-pyran-2-yl benzoate |
| CENSA-036 | 106-45-6 | 4-methylbenzenethiol |
| CENSA-037 | 1498325-15-7 | (2S,3R)-5-oxo-3-(p-tolylthio)tetrahydro-2H-pyran-2-yl benzoate |
| CENSA-038 | 54655-07-1 | ((trimethylsilyl)ethynyl)lithium |
| CENSA-039 | 1498325-08-8 | (2S,3R,5R)-5-hydroxy-3-(p-tolylthio)-5-((trimethylsilyl)ethynyl)tetrahydro-2H-pyran-2-yl benzoate |
| CENSA-040 | 1498325-19-1 | (3R,5R)-5-(hydroxymethyl)-3-(p-tolylthio)-5-((trimethylsilyl)ethynyl)tetrahydrofuran-2-ol |
| CENSA-041 | 1498325-23-7 | ((2R,4R,5R)-5-(benzoyloxy)-4-(p-tolylthio)-2-((trimethylsilyl)ethynyl)tetrahydrofuran-2-yl)methyl benzoate |
| CENSA-042 | 1498325-10-2 | ((2R,4R,5R)-5-(benzoyloxy)-2-ethynyl-4-(p-tolylthio)tetrahydrofuran-2-yl)methyl benzoate |
| CENSA-043 | 7288-28-0 | 5-methyl-2,4-bis((trimethylsilyl)oxy)pyrimidine |
| CENSA-044 | 1498325-12-4 | ((2R,4R,5R)-2-ethynyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(p-tolylthio)tetrahydrofuran-2-yl)methyl benzoate |
| CENSA-045 | 744217-17-2 | ((2R,5R)-2-ethynyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate |
| Censavudine | 634907-30-5 | 1-((2R,5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione |
常见问题（FAQ）
Censavudine的适应症有哪些？
已批准的适应症包括：进行性核上性麻痹、额颞痴呆、肌萎缩性侧索硬化、Aicardi综合征、HIV感染。
Censavudine的专利什么时候到期？
Censavudine的专利到期年暂无公开口径，本页会在数据管道核实后更新。
Censavudine有几条合成路线？
本站收录 4 条合成路线，最短路线 8 步、总收率 275 mg。每条路线的中间体均带登记编号与 CAS 号。
Censavudine的关键中间体在哪里可以采购？
Censavudine的多条路线中间体已挂接 CAS 档案，其中 1 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取Censavudine中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-19