丙酸氟替卡松

Tier C · 观察 / 贸易

Fluticasone Propionate

葛兰素史克

原研

1990

首批上市

到期年（公开口径）

无销量数据

峰值销售

化学药

类型

靶点：GR、PLA2G4A

商品名：Flonase、Flutide、Flixotide/Flovent、辅舒拿、Cutivate、Flixotide、Flovent

适应症（已批准）：鼻塞、过敏性鼻炎、鼻息肉、鼻炎、扁平苔藓、红疹、接触性皮炎、盘状红斑狼疮

各地区研发/上市状态

美国

批准上市

1990-12-14

欧盟

临床三期

1999-11-01

中国

批准上市

2000-06-16

日本

批准上市

2001-10-02

合成路线与中间体6 routes

原研路线 × 0优化路线（非专利）× 6工艺路线 × 0

路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。

优化Route 1步骤 5 · 总收率 3.6 g (Fluticasone propionate)

FLUTI-00128416-82-2FLUTI-00280473-92-3FLUTI-00380474-45-9FLUTI-00480486-69-7FLUTI-00580474-67-5Fluticasone propionate90566-53-3API · 丙酸氟替卡松

编号	CAS 号	中间体名称
FLUTI-001	28416-82-2	(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid
FLUTI-002	80473-92-3	(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid
FLUTI-003	80474-45-9	(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid
FLUTI-004	80486-69-7	(6S,8S,9R,10S,11S,13S,14S,16R,17R)-17-(((chloromethyl)thio)carbonyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
FLUTI-005	80474-67-5	(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-17-(((iodomethyl)thio)carbonyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
Fluticasone propionate	90566-53-3	-

优化Route 2步骤 6 · 总收率 83.5 g (Fluticasone propionate)

FLUTI-00128416-82-2FLUTI-00380474-45-9FLUTI-0061744-65-6FLUTI-00765429-42-7FLUTI-00816420-13-6FLUTI-009105638-31-1FLUTI-0101351451-82-5API · 丙酸氟替卡松

编号	CAS 号	中间体名称
FLUTI-001	28416-82-2	(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid
FLUTI-003	80474-45-9	(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid
FLUTI-006	1744-65-6	(6S,8S,9R,10S,11S,13S,14S,16R,17R)-17-acetyl-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
FLUTI-007	65429-42-7	(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid
FLUTI-008	16420-13-6	dimethylcarbamothioic chloride
FLUTI-009	105638-31-1	(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic dimethylcarbamic thioanhydride
FLUTI-010	1351451-82-5	2-(((6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)thio)acetic acid

优化Route 3步骤 5 · 总收率 0.041 g (Fluticasone propionate)

FLUTI-00380474-45-9FLUTI-0115292-43-3FLUTI-0121414857-52-5FLUTI-0131414857-53-6FLUTI-0141414857-54-7FLUTI-0151414857-56-9API · 丙酸氟替卡松

编号	CAS 号	中间体名称
FLUTI-003	80474-45-9	(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid
FLUTI-011	5292-43-3	tert-butyl 2-bromoacetate
FLUTI-012	1414857-52-5	(6S,9R,10S,11S,13S,16R,17R)-17-(((2-(tert-butoxy)-2-oxoethyl)thio)carbonyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
FLUTI-013	1414857-53-6	(6S,9R,10S,11S,13S,16R,17R)-17-(((2-(tert-butoxy)-2-oxoethyl)thio)carbonyl)-6,9-difluoro-10,13,16-trimethyl-3-oxo-11-(2,2,2-trifluoroacetoxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
FLUTI-014	1414857-54-7	2-(((6S,9R,10S,11S,13S,16R,17R)-6,9-difluoro-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-11-(2,2,2-trifluoroacetoxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)thio)acetic acid
FLUTI-015	1414857-56-9	(6S,9R,10S,11S,13S,16R,17R)-6,9-difluoro-17-(((fluoromethyl)thio)carbonyl)-10,13,16-trimethyl-3-oxo-11-(2,2,2-trifluoroacetoxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate

优化Route 4步骤 2 · 总收率 0.4 g (Fluticasone propionate)

FLUTI-00380474-45-9FLUTI-0101351451-82-5FLUTI-01679-08-3API · 丙酸氟替卡松

编号	CAS 号	中间体名称
FLUTI-003	80474-45-9	(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid
FLUTI-010	1351451-82-5	2-(((6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)thio)acetic acid
FLUTI-016	79-08-3	2-bromoacetic acid

优化Route 5步骤 2 · 总收率 72.9 g (FLUT-015)

FLUTI-017—FLUTI-018—FLUTI-019—API · 丙酸氟替卡松

编号	CAS 号	中间体名称
FLUTI-017	-	(6S,9R,10S,11S,13S,16R,E)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-17-(1-((trimethylsilyl)oxy)ethylidene)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
FLUTI-018	-	(6S,9R,10S,11S,13S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-17-(2-((trimethylsilyl)oxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
FLUTI-019	-	(6S,9R,10S,11S,13S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

优化Route 6步骤 6 · 总收率 254.5 mg (FLUT-027)

FLUTI-023—FLUTI-02437413-91-5FLUTI-025—FLUTI-026—FLUTI-027—FLUTI-02050-24-8FLUTI-021—FLUTI-022108-24-7API · 丙酸氟替卡松

编号	CAS 号	中间体名称
FLUTI-023	-	(Z)-1-((8S,10S,13S,14S)-10,13-dimethyl-3-oxo-7,8,12,13,15,16-hexahydro-3H-cyclopenta[a]phenanthren-17(6H,10H,14H)-ylidene)-2-oxoethyl acetate
FLUTI-024	37413-91-5	2-((8S,10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
FLUTI-025	-	2-((8S,9R,10S,11S,13S,14S)-9-bromo-11-(formyloxy)-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
FLUTI-026	-	2-((4aS,4bS,5aS,6aS,9aS,9bS)-4a,6a-dimethyl-2-oxo-2,4a,5a,6,6a,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl)-2-oxoethyl acetate
FLUTI-027	-	2-((4aS,4bS,5aS,6aS,7R,8R,9aS,9bS)-7-hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl)-2-oxoethyl acetate
FLUTI-020	50-24-8	(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
FLUTI-021	-	(Z)-2-((8S,10S,13S,14S)-10,13-dimethyl-3-oxo-7,8,12,13,15,16-hexahydro-3H-cyclopenta[a]phenanthren-17(6H,10H,14H)-ylidene)-2-hydroxyacetaldehyde
FLUTI-022	108-24-7	acetic anhydride

常见问题（FAQ）

丙酸氟替卡松的适应症有哪些？

已批准的适应症包括：鼻塞、过敏性鼻炎、鼻息肉、鼻炎、扁平苔藓、红疹、接触性皮炎、盘状红斑狼疮。

丙酸氟替卡松的专利什么时候到期？

丙酸氟替卡松的专利到期年暂无公开口径，本页会在数据管道核实后更新。

丙酸氟替卡松有几条合成路线？

本站收录 6 条合成路线，最短路线 2 步、总收率 0.4 g (Fluticasone propionate)。每条路线的中间体均带登记编号与 CAS 号。

丙酸氟替卡松的关键中间体在哪里可以采购？

丙酸氟替卡松路线中的中间体均已建立 CAS 档案，可直接按 CAS 发起询价，需求会进入供应网络撮合池。

如何获取丙酸氟替卡松中间体的报价？

在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。

数据来源：多源数据交叉核实（仅结构化字段） · 2026-09-27