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替尔泊肽
Tier B · 提前布局Tirzepatide · 2036 年到期全部品种 →
礼来制药
原研
2022
首批上市
2036
到期年（公开口径）
$36.51B ▲
峰值销售
化学药
类型
靶点：GLP1R、GIPR
商品名：ZEPBOUND KwikPen、穆峰达、Mounjaro、Mounjaro KwikPen、Zepbound
适应症（已批准）：阻塞性睡眠呼吸暂停综合征、肥胖症、超重、二型糖尿病
各地区研发/上市状态
美国
批准上市
2022-05-13
欧盟
批准上市
2022-09-15
中国
批准上市
2024-05-15
日本
批准上市
2022-09-26
合成路线与中间体9 routes
原研路线 × 0优化路线（非专利）× 9工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 18 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tirzepatide-001 | 71989-33-8在售 | Fmoc-O-tert-butyl-L-serine |
| Tirzepatide-002 | - | Resin bound O-tert-butyl-L-serinamide |
| Tirzepatide-003 | - | Resin bound L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-004 | - | Resin bound L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-005 | - | Resin bound O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-006 | - | Resin bound L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-007 | - | Resin bound L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-008 | - | Resin bound Gly-Pro-Pro-Pro-Ser(tBu)-NH |
| Tirzepatide-009 | - | Resin bound O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-010 | - | Resin bound L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-011 | - | Resin bound glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-012 | - | Resin bound N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-013 | - | Resin bound L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-014 | - | Resin bound L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-015 | - | Resin bound L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-016 | - | Resin bound 1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-017 | - | Resin bound N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-018 | - | Resin bound L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
优化Route 2步骤 9 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tirzepatide-019 | - | Resin bound L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-020 | - | Resin bound L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-021 | - | Resin bound N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-022 | - | Resin bound N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-023 | - | Resin bound L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-024 | - | Resin bound L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-025 | - | Resin bound N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-026 | - | Resin bound 4-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl--N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-Isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-027 | - | Resin bound L-leucyl-4-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-018 | - | Resin bound L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
优化Route 3步骤 10 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tirzepatide-028 | - | Resin bound L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-029 | - | Resin bound 2-methylalanyl-L-leucyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-Isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-030 | - | Resin bound O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-031 | - | Resin bound O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-032 | - | Resin bound O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-033 | - | Resin bound O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-034 | - | Resin bound O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-035 | - | Resin bound L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-036 | - | Resin bound O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-027 | - | Resin bound L-leucyl-4-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
优化Route 4步骤 6 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tirzepatide-037 | - | Resin bound N-(tert-butoxycarbonyl)-O-tert-butyl-L-tyrosyl-2-methylalanyl-O-tert-butyl-L-alpha-glutamylglycyl-O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-038 | - | Resin bound 2-methylalanyl-5-O-tert-butyl-L-alpha-glutamylglycyl-3-O-tert-butyl-L-threonyl-L-phenylalanyl-3-O-tert-butyl-L-threonyl-3-O-tert-butyl-L-seryl-4-O-tert-butyl-L-alpha-aspartyl-4-O'-tert-butyl-L-tyrosyl-3-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-4-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-5-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-5-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
| Tirzepatide-036 | - | Resin bound O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-039 | - | Resin bound glycyl-3-O-tert-butyl-L-threonyl-L-phenylalanyl-3-O-tert-butyl-L-threonyl-3-O-tert-butyl-L-seryl-4-O-tert-butyl-L-alpha-aspartyl-4'-O-tert-butyl-L-tyrosyl-3-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-4-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-5-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-5-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
| Tirzepatide-040 | - | Resin bound 5-O-tert-butyl-L-alpha-glutamylglycyl-3-O-tert-butyl-L-threonyl-L-phenylalanyl-3-O-tert-butyl-L-threonyl-3-O-tert-butyl-L-seryl-4-O-tert-butyl-L-alpha-aspartyl-4'-O-tert-butyl-L-tyrosyl-3-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-4-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-5-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-5-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
优化Route 5步骤 13 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tirzepatide-041 | - | Resin bound Glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-042 | - | Resin bound L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-043 | - | Resin bound L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-044 | - | Resin bound L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-045 | - | Resin bound L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-046 | - | Resin bound 1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-047 | - | Resin bound N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-048 | - | Resin bound L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-049 | - | Resin bound L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-050 | - | Resin bound N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-051 | - | Resin bound N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-052 | - | Resin bound N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-053 | - | Resin bound N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-Glycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-019 | - | Resin bound L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-020 | - | Resin bound L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-010 | - | Resin bound L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-011 | - | Resin bound glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-012 | - | Resin bound glycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-013 | - | Resin bound L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-018 | - | Resin bound L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-014 | - | Resin bound L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-015 | - | Resin bound L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-016 | - | Resin bound 1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-017 | - | Resin bound N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
优化Route 6步骤 10 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tirzepatide-054 | - | Resin bound L-Alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-055 | - | Resin bound L-Alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-056 | - | Resin bound 2-Methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-057 | - | Resin bound 2-Methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-058 | - | Resin bound L-Isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-059 | - | Resin bound L-Isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-060 | - | Resin bound N6-(tert-Butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-061 | - | Resin bound N6-(tert-Butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-062 | - | Resin bound O-tert-Butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-063 | - | Resin bound O-tert-Butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-064 | - | Resin bound L-Leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-065 | - | Resin bound L-Leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-066 | - | Resin bound L-Isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-067 | - | Resin bound L-Isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-068 | - | Resin bound O-tert-Butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-069 | - | Resin bound O-tert-Butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-070 | - | Resin bound O-tert-Butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-071 | - | Resin bound O-tert-Butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-052 | - | Resin bound N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-053 | - | Resin bound N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-Glycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
优化Route 7步骤 8 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tirzepatide-072 | - | Resin bound O-tert-Butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-073 | - | Resin bound O-tert-Butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-074 | - | O-tert-Butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-075 | - | Resin bound O-tert-Butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-076 | - | Resin bound O-tert-Butyl-L-alpha-glutamylglycyl-O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-077 | - | Resin bound O-tert-Butyl-L-alpha-glutamylglycyl-O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-078 | - | Resin bound O-tert-Butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-079 | - | Resin bound O-tert-Butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-080 | - | Resin bound L-Phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-081 | - | Resin bound L-Phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-082 | - | Resin bound O-tert-Butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-083 | - | Resin bound O-tert-Butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-084 | - | Resin bound Glycyl-O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-085 | - | Resin bound Glycyl-O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-070 | - | Resin bound O-tert-Butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-071 | - | Resin bound O-tert-Butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
优化Route 8步骤 3 · 总收率 23.8g(Tirzepatide)
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tirzepatide-086 | - | Resin bound 2-Methylalanyl-5-O-tert-butyl-L-alpha-glutamylglycyl-3-O-tert-butyl-L-threonyl-L-phenylalanyl-3-O-tert-butyl-L-threonyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-3-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-4-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
| Tirzepatide-087 | - | Resin bound 2-Methylalanyl-5-O-tert-butyl-L-alpha-glutamylglycyl-3-O-tert-butyl-L-threonyl-L-phenylalanyl-3-O-tert-butyl-L-threonyl-3-O-tert-butyl-L-seryl-4-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-3-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-4-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-5-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
| Tirzepatide-088 | - | Resin bound O-tert-Butyl-L-tyrosyl-2-methylalanyl-5-O-tert-butyl-L-alpha-glutamylglycyl-3-O-tert-butyl-L-threonyl-L-phenylalanyl-3-O-tert-butyl-L-threonyl-3-O-tert-butyl-L-seryl-4-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-3-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-N-[(2S)-6-(tert-butyloxycarbonylamino)-1-oxohexan-2-yl]-4-O-tert-butyl-L-alpha-asparaginyl-L-Isoleucyl-L-alanyl-5-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-5-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
| Tirzepatide-089 | - | Resin bound O-tert-Butyl-L-tyrosyl-2-methylalanyl-5-O-tert-butyl-L-alpha-glutamylglycyl-3-O-tert-butyl-L-threonyl-L-phenylalanyl-3-O-tert-butyl-L-threonyl-3-O-tert-butyl-L-seryl-4-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-3-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-N-[(2S)-6-(tert-butyloxycarbonylamino)-1-oxohexan-2-yl]-4-O-tert-butyl-L-alpha-asparaginyl-L-Isoleucyl-L-alanyl-5-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-5-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
| Tirzepatide-076 | - | Resin bound O-tert-Butyl-L-alpha-glutamylglycyl-O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-077 | - | Resin bound O-tert-Butyl-L-alpha-glutamylglycyl-O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
优化Route 9步骤 4 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tirzepatide-090 | - | - |
| Tirzepatide-091 | - | - |
| Tirzepatide-092 | - | L-Phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-093 | - | (2S,5S,32S)-5-[[(5S,8S,11S,14S,17S)-11-[(2S)-Butan-2-yl]-8-[4-[(tert-butoxycarbonyl)amino]butyl]-5-(2-tert-butoxy-2-oxoethyl)-1-(9H-fluoren-9-yl)-14-methyl-3,6,9,12,15,18-hexaoxo-17-[3-oxo-3-[(triphenylmethyl)amino]propyl]-2-oxa-4,7,10,13,16-pentaazaoctadecan-18-yl]amino]-32-(tert-butoxycarbonyl)-2,55,55-trimethyl-4,11,20,29,34,53-hexaoxo-13,16,22,25,54-pentaoxa-3,10,19,28,33-pentaazahexapentacontan-1-oic acid |
| Tirzepatide-094 | - | 4-O-tert-Butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-5-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-1-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-5-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
| Tirzepatide-095 | - | N-(tert-Butoxycarbonyl)-4'-O-tert-butyl-L-tyrosyl-2-methylalanyl-5-O-tert-butyl-L-alpha-glutamylglycyl-3-O-tert-butyl-L-threonyl-L-phenylalanyl-3-O-tert-butyl-L-threonyl-3-O-tert-butyl-L-seryl-4-O-tert-butyl-L-alpha-aspartyl-4'-O-tert-butyl-L-tyrosyl-3-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucine |
| Tirzepatide-096 | - | - |
该分子在多肽现货货盘中的报价
常见问题（FAQ）
替尔泊肽的适应症有哪些？
已批准的适应症包括：阻塞性睡眠呼吸暂停综合征、肥胖症、超重、二型糖尿病。
替尔泊肽的专利什么时候到期？
按公开口径，替尔泊肽的专利到期年为 2036 年。
替尔泊肽有几条合成路线？
本站收录 9 条合成路线，最短路线 3 步、总收率 23.8g(Tirzepatide)。每条路线的中间体均带登记编号与 CAS 号。
替尔泊肽的关键中间体在哪里可以采购？
替尔泊肽的多条路线中间体已挂接 CAS 档案，其中 1 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取替尔泊肽中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-09-24