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非那沙星
Tier C · 观察 / 贸易Finafloxacin
英国爱尔康公司
原研
2014
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：Topoisomerase IV、Bacterial DNA gyrase
商品名：Xtoro
适应症（已批准）：外耳炎
各地区研发/上市状态
美国
批准上市
2014-12-17
欧盟
无进展
2008-09-01
中国
-
日本
-
合成路线与中间体2 routes
原研路线 × 1优化路线（非专利）× 1工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 19 · 总收率 90 g
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| FINA-001 | 461-97-2 | 1-fluoro-3,5-dimethylbenzene |
| FINA-002 | 214774-61-5 | 2,4-dichloro-1-fluoro-3,5-dimethylbenzene |
| FINA-003 | 214774-60-4 | 2,4-dichloro-3-(dichloromethyl)-1-fluoro-5-(trichloromethyl)benzene |
| FINA-004 | 214774-58-0 | 2,4-dichloro-5-fluoro-3-formylbenzoic acid |
| FINA-005 | 214774-57-9 | (Z)-2,4-dichloro-5-fluoro-3-((hydroxyimino)methyl)benzoic acid |
| FINA-006 | 117528-59-3 | 2,4-dichloro-3-cyano-5-fluorobenzoyl chloride |
| FINA-007 | 924-99-2 | (Z)-ethyl 3-(dimethylamino)acrylate |
| FINA-008 | 1159908-25-4 | ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-(dimethylamino)acrylate |
| FINA-009 | 86483-52-5在售 | cyclopropanamine |
| FINA-010 | 117528-63-9 | ethyl 3-(cyclopropylamino)-2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)acrylate |
| FINA-011 | 117528-64-0 | ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate |
| FINA-012 | 117528-65-1 | 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| FINA-013 | 209401-69-4 | (4aS,7aS)-octahydropyrrolo[3,4-b][1,4]oxazine |
| FINA-014 | 821-11-4 | (E)-but-2-ene-1,4-diol |
| FINA-015 | 16851-72-2 | 1-tosyl-2,5-dihydro-1H-pyrrole |
| FINA-016 | 159555-66-5 | 3-tosyl-6-oxa-3-azabicyclo[3.1.0]hexane |
| FINA-017 | 141-43-5在售 | 2-aminoethan-1-ol |
| FINA-018 | - | 4-((2-hydroxyethyl)amino)-1-tosylpyrrolidin-3-ol |
| FINA-019 | - | 2-(N-(4-hydroxy-1-tosylpyrrolidin-3-yl)-4-methylphenylsulfonamido)ethyl 4-methylbenzenesulfonate |
| FINA-020 | - | 4,6-ditosyloctahydropyrrolo[3,4-b][1,4]oxazine |
| FINA-021 | - | (4aS,7aS)-4,6-ditosyloctahydropyrrolo[3,4-b][1,4]oxazine |
优化Route 2步骤 24 · 总收率 21 g
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| FINA-006 | 117528-59-3 | 2,4-dichloro-3-cyano-5-fluorobenzoyl chloride |
| FINA-007 | 924-99-2 | (Z)-ethyl 3-(dimethylamino)acrylate |
| FINA-008 | 1159908-25-4 | ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-(dimethylamino)acrylate |
| FINA-009 | 86483-52-5在售 | cyclopropanamine |
| FINA-010 | 117528-63-9 | ethyl 3-(cyclopropylamino)-2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)acrylate |
| FINA-011 | 117528-64-0 | ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate |
| FINA-014 | 821-11-4 | (E)-but-2-ene-1,4-diol |
| FINA-015 | 16851-72-2 | 1-tosyl-2,5-dihydro-1H-pyrrole |
| FINA-016 | 159555-66-5 | 3-tosyl-6-oxa-3-azabicyclo[3.1.0]hexane |
| FINA-022 | 1435-48-9 | 2,4-dichloro-1-fluorobenzene |
| FINA-023 | 704-10-9 | 1-(2,4-dichloro-5-fluorophenyl)ethanone |
| FINA-024 | 86522-89-6 | 2,4-dichloro-5-fluorobenzoic acid |
| FINA-025 | 106809-14-7 | 2,4-dichloro-5-fluoro-3-nitrobenzoic acid |
| FINA-026 | 1153285-12-1 | methyl 2,4-dichloro-5-fluoro-3-nitrobenzoate |
| FINA-027 | 1159908-24-3 | methyl 3-amino-2,4-dichloro-5-fluorobenzoate |
| FINA-028 | 220035-64-3 | methyl 2,4-dichloro-3-cyano-5-fluorobenzoate |
| FINA-029 | 117528-58-2 | 2,4-dichloro-3-cyano-5-fluorobenzoic acid |
| FINA-030 | 1159908-23-2 | (4aS,7aS)-tert-butyl hexahydropyrrolo[3,4-b][1,4]oxazine-4(4aH)-carboxylate |
| FINA-031 | 1159908-26-5 | (4aS,7aS)-tert-butyl 6-(8-cyano-1-cyclopropyl-3-(ethoxycarbonyl)-6-fluoro-4-oxo-1,4-dihydroquinolin-7-yl)hexahydropyrrolo[3,4-b][1,4]oxazine-4(4aH)-carboxylate |
| FINA-032 | 1159908-27-6 | 7-((4aS,7aS)-4-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl)-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| FINA-033 | 110-57-6 | (E)-1,4-dichlorobut-2-ene |
| FINA-034 | 3886-69-9在售 | (R)-1-phenylethan-1-amine |
| FINA-035 | 1159908-18-5 | (3S,4S)-4-(((R)-1-phenylethyl)amino)-1-tosylpyrrolidin-3-ol |
| FINA-036 | 79-04-9在售 | 2-chloroacetyl chloride |
| FINA-037 | 1159908-19-6 | 2-chloro-N-((3S,4S)-4-hydroxy-1-tosylpyrrolidin-3-yl)-N-((R)-1-phenylethyl)acetamide |
| FINA-038 | 1159908-20-9 | (4aS,7aS)-4-((R)-1-phenylethyl)-6-tosylhexahydropyrrolo[3,4-b][1,4]oxazin-3(2H)-one |
| FINA-039 | 1159908-21-0 | (4aS,7aS)-4-((R)-1-phenylethyl)-6-tosyloctahydropyrrolo[3,4-b][1,4]oxazine |
| FINA-040 | 159651-47-5 | (4aS,7aS)-6-tosyloctahydropyrrolo[3,4-b][1,4]oxazine |
| FINA-041 | 1159908-22-1 | (4aS,7aS)-tert-butyl 6-tosylhexahydropyrrolo[3,4-b][1,4]oxazine-4(4aH)-carboxylate |
常见问题（FAQ）
非那沙星的适应症有哪些？
已批准的适应症包括：外耳炎。
非那沙星的专利什么时候到期？
非那沙星的专利到期年暂无公开口径，本页会在数据管道核实后更新。
非那沙星有几条合成路线？
本站收录 2 条合成路线，最短路线 19 步、总收率 90 g。每条路线的中间体均带登记编号与 CAS 号。
非那沙星的关键中间体在哪里可以采购？
非那沙星的多条路线中间体已挂接 CAS 档案，其中 4 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取非那沙星中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-09-24