卡泊三醇

Tier C · 观察 / 贸易

Calcipotriol

丹麦利奥制药有限公司

原研

1990

首批上市

到期年（公开口径）

无销量数据

峰值销售

化学药

类型

靶点：VDR

商品名：Daivonex、Divonex、Psorcutan、Dovonex、Sorilux

适应症（已批准）：银屑病、斑块银屑病

各地区研发/上市状态

美国

批准上市

1993-12-29

欧盟

无进展

2015-11-23

中国

批准上市

2001-08-07

日本

合成路线与中间体4 routes

原研路线 × 1优化路线（非专利）× 3工艺路线 × 0

路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。

原研Route 1步骤 15 · 总收率 483 mg (Calcipotriol)

CALCIP-00150-14-6CALCIP-00287680-65-7CALCIP-003170081-43-3CALCIP-00460123-29-7CALCIP-005112670-78-7CALCIP-006111594-58-2CALCIP-0072170464-36-3CALCIP-008—CALCIP-009—CALCIP-0107691-76-1CALCIP-011112849-17-9CALCIP-012112849-27-1CALCIP-013112849-27-1CALCIP-014765-43-5CALCIP-01569267-75-0CALCIP-016112849-15-7API · 卡泊三醇

编号	CAS 号	中间体名称
CALCIP-001	50-14-6 在售	(S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol
CALCIP-002	87680-65-7 在售	(6S)-1-((E)-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)methyl)-6-hydroxy-1,3,4,5,6,7-hexahydrobenzo[c]thiophene 2,2-dioxide
CALCIP-003	170081-43-3 在售	2-((1R,3aS,7aR,E)-4-(((6S)-6-((tert-butyldimethylsilyl)oxy)-2,2-dioxido-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal
CALCIP-004	60123-29-7 在售	tert-butyl(((S,E)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)dimethylsilane
CALCIP-005	112670-78-7 在售	(1S,5R,E)-5-((tert-butyldimethylsilyl)oxy)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-2-methylenecyclohexanol
CALCIP-006	111594-58-2 在售	(((1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane)
CALCIP-007	2170464-36-3 在售	(4S,6R)-4,6-bis((tert-butyldimethylsilyl)oxy)-1-((E)-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)methyl)octahydrobenzo[c]thiophene 2,2-dioxide
CALCIP-008	-	(2S)-2-((1R,3aS,7aR,E)-4-(((4S,6R)-4,6-bis((tert-butyldimethylsilyl)oxy)-2,2-dioxidooctahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal
CALCIP-009	-	2-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)propanal
CALCIP-010	7691-76-1 在售	1-cyclopropyl-2-(triphenylphosphoranylidene)ethanone
CALCIP-011	112849-17-9 在售	(R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-one
CALCIP-012	112849-27-1 在售	(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol
CALCIP-013	112849-27-1 在售	(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol
CALCIP-014	765-43-5 在售	1-cyclopropylethanone
CALCIP-015	69267-75-0 在售	2-bromo-1-cyclopropylethanone
CALCIP-016	112849-15-7 在售	-

优化Route 2步骤 3 · 总收率 89 mg (Calcipotriol)

CALCIP-017223538-02-1CALCIP-0181099618-83-3CALCIP-0191099618-85-5CALCIP-0201099618-87-7API · 卡泊三醇

编号	CAS 号	中间体名称
CALCIP-017	223538-02-1 在售	(((1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-7a-methyl-1-((S)-1-(phenylsulfonyl)propan-2-yl)hexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane)
CALCIP-018	1099618-83-3 在售	(S)-2-((tert-butyldiphenylsilyl)oxy)-2-cyclopropylacetaldehyde
CALCIP-019	1099618-85-5 在售	(1S,4S)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-((tert-butyldiphenylsilyl)oxy)-1-cyclopropyl-3-(phenylsulfonyl)pentan-2-ol
CALCIP-020	1099618-87-7 在售	(((1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5-((tert-butyldiphenylsilyl)oxy)-5-cyclopropylpent-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane)

优化Route 3步骤 12 · 总收率 22.6 g (Calcipotriol)

CALCIP-00150-14-6CALCIP-00287680-65-7CALCIP-003170081-43-3CALCIP-021170081-43-3CALCIP-0221329004-02-5CALCIP-023—CALCIP-024—CALCIP-025—CALCIP-0107691-76-1CALCIP-026—CALCIP-027—CALCIP-011112849-17-9CALCIP-012112849-27-1CALCIP-013112849-27-1API · 卡泊三醇

编号	CAS 号	中间体名称
CALCIP-001	50-14-6 在售	(S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol
CALCIP-002	87680-65-7 在售	(6S)-1-((E)-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)methyl)-6-hydroxy-1,3,4,5,6,7-hexahydrobenzo[c]thiophene 2,2-dioxide
CALCIP-003	170081-43-3 在售	2-((1R,3aS,7aR,E)-4-(((6S)-6-((tert-butyldimethylsilyl)oxy)-2,2-dioxido-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal
CALCIP-021	170081-43-3 在售	2-((1R,3aS,7aR,E)-4-(((6S)-6-((tert-butyldimethylsilyl)oxy)-2,2-dioxido-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal
CALCIP-022	1329004-02-5 在售	2-((1R,3aS,7aR,E)-4-((E)-2-((S)-5-((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)propanal
CALCIP-023	-	-
CALCIP-024	-	-
CALCIP-025	-	-
CALCIP-010	7691-76-1 在售	1-cyclopropyl-2-(triphenylphosphoranylidene)ethanone
CALCIP-026	-	-
CALCIP-027	-	-
CALCIP-011	112849-17-9 在售	(R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-one
CALCIP-012	112849-27-1 在售	(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol
CALCIP-013	112849-27-1 在售	(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol

优化Route 4步骤 9 · 总收率 198 mg (Calcipotriol)

CALCIP-0281342554-01-1CALCIP-029—CALCIP-030—CALCIP-0311971117-00-6CALCIP-0321971117-03-9CALCIP-033149-30-4CALCIP-0341971117-04-0CALCIP-0351971117-11-9CALCIP-036112828-13-4CALCIP-0381971117-18-6CALCIP-0371971117-18-6API · 卡泊三醇

编号	CAS 号	中间体名称
CALCIP-028	1342554-01-1 在售	-
CALCIP-029	-	-
CALCIP-030	-	-
CALCIP-031	1971117-00-6 在售	-
CALCIP-032	1971117-03-9 在售	-
CALCIP-033	149-30-4 在售	-
CALCIP-034	1971117-04-0 在售	-
CALCIP-035	1971117-11-9 在售	-
CALCIP-036	112828-13-4 在售	-
CALCIP-038	1971117-18-6 在售	benzyl ((1S,4R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-yl) carbonate
CALCIP-037	1971117-18-6 在售	benzyl ((1S,4R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-yl) carbonate

常见问题（FAQ）

卡泊三醇的适应症有哪些？

已批准的适应症包括：银屑病、斑块银屑病。

卡泊三醇的专利什么时候到期？

卡泊三醇的专利到期年暂无公开口径，本页会在数据管道核实后更新。

卡泊三醇有几条合成路线？

本站收录 4 条合成路线，最短路线 3 步、总收率 89 mg (Calcipotriol)。每条路线的中间体均带登记编号与 CAS 号。

卡泊三醇的关键中间体在哪里可以采购？

卡泊三醇的多条路线中间体已挂接 CAS 档案，其中 26 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。

如何获取卡泊三醇中间体的报价？

在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。

数据来源：多源数据交叉核实（仅结构化字段） · 2026-09-27