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曲前列尼尔
Tier C · 观察 / 贸易Treprostinil
联合治疗公司
原研
2002
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：PTGIR
商品名：Remodulin、瑞莫杜林、Orenitram、Tyvaso、Trepulmix
适应症（已批准）：间质性肺疾病、肺性高血压、肺动脉高压
各地区研发/上市状态
美国
批准上市
2002-05-21
欧盟
批准上市
2020-04-03
中国
批准上市
2013-03-26
日本
批准上市
2019-03-24
合成路线与中间体5 routes
原研路线 × 1优化路线（非专利）× 4工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 10 · 总收率 /
TREP-00165423-57-6TREP-00230004-67-2TREP-003—TREP-00481846-25-5TREP-00581846-26-6TREP-006—TREP-00781872-06-2TREP-00881846-28-8TREP-00996-32-2TREP-01081846-29-9TREP-01181845-87-6TREP-01281845-88-7API · 曲前列尼尔
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| TREP-001 | 65423-57-6在售 | (2R,3R,4R)-2-(3-((tert-butyldimethylsilyl)oxy)benzyl)-4-((tetrahydro-2H-pyran-2-yl)oxy)-3-((3S,E)-3-((tetrahydro-2H-pyran-2-yl)oxy)oct-1-en-1-yl)cyclopentan-1-one |
| TREP-002 | 30004-67-2在售 | methyl(methylimino)(phenyl)-l6-sulfanone |
| TREP-003 | - | (((2R,3R,4R)-2-(3-((tert-butyldimethylsilyl)oxy)benzyl)-4-((tetrahydro-2H-pyran-2-yl)oxy)-3-((3S,E)-3-((tetrahydro-2H-pyran-2-yl)oxy)oct-1-en-1-yl)cyclopentyl)methyl)(methylimino)(phenyl)-l6-sulfanone |
| TREP-004 | 81846-25-5在售 | tert-butyldimethyl(3-(((1R,2R,3R)-5-methylene-3-((tetrahydro-2H-pyran-2-yl)oxy)-2-((3S,E)-3-((tetrahydro-2H-pyran-2-yl)oxy)oct-1-en-1-yl)cyclopentyl)methyl)phenoxy)silane |
| TREP-005 | 81846-26-6在售 | ((1S,2S,3R,4R)-2-(3-((tert-butyldimethylsilyl)oxy)benzyl)-4-((tetrahydro-2H-pyran-2-yl)oxy)-3-((3S,E)-3-((tetrahydro-2H-pyran-2-yl)oxy)oct-1-en-1-yl)cyclopentyl)methanol |
| TREP-006 | - | ((1S,2S,3R,4R)-2-(3-((tert-butyldimethylsilyl)oxy)benzyl)-4-((tetrahydro-2H-pyran-2-yl)oxy)-3-((3S,E)-3-((tetrahydro-2H-pyran-2-yl)oxy)oct-1-en-1-yl)cyclopentyl)methyl methanesulfonate |
| TREP-007 | 81872-06-2在售 | ((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-((tetrahydro-2H-pyran-2-yl)oxy)-3-((3S,E)-3-((tetrahydro-2H-pyran-2-yl)oxy)oct-1-en-1-yl)cyclopentyl)methyl methanesulfonate |
| TREP-008 | 81846-28-8在售 | (1R,2R,3aS,9aS)-2-((tetrahydro-2H-pyran-2-yl)oxy)-1-((3S,E)-3-((tetrahydro-2H-pyran-2-yl)oxy)oct-1-en-1-yl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-ol |
| TREP-009 | 96-32-2在售 | methyl 2-bromoacetate |
| TREP-010 | 81846-29-9在售 | methyl 2-(((1R,2R,3aS,9aS)-2-((tetrahydro-2H-pyran-2-yl)oxy)-1-((3S,E)-3-((tetrahydro-2H-pyran-2-yl)oxy)oct-1-en-1-yl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetate |
| TREP-011 | 81845-87-6在售 | methyl 2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S,E)-3-hydroxyoct-1-en-1-yl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetate |
| TREP-012 | 81845-88-7在售 | 2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S,E)-3-hydroxyoct-1-en-1-yl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetic acid |
优化Route 2步骤 14 · 总收率 /
TREP-01320739-58-6TREP-01422104-78-5TREP-015—TREP-016193292-90-9TREP-0171265205-18-2TREP-018150311-88-9TREP-019—TREP-020756-79-6TREP-021—TREP-022101691-57-0TREP-023101691-99-0TREP-024223734-61-0TREP-025101758-86-5TREP-026101692-01-7TREP-027101692-02-8TREP-028107-14-2TREP-029101692-03-9API · 曲前列尼尔
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| TREP-013 | 20739-58-6在售 | oct-2-yn-1-ol |
| TREP-014 | 22104-78-5在售 | (E)-oct-2-en-1-ol |
| TREP-015 | - | ((2R,3R)-3-pentyloxiran-2-yl)methanol |
| TREP-016 | 193292-90-9在售 | (S)-octane-1,3-diol |
| TREP-017 | 1265205-18-2在售 | (S)-3-hydroxyoctyl 4-methylbenzenesulfonate |
| TREP-018 | 150311-88-9在售 | (S)-1-iodooctan-3-ol |
| TREP-019 | - | 2-(((S)-1-iodooctan-3-yl)oxy)tetrahydro-2H-pyran |
| TREP-020 | 756-79-6在售 | dimethyl methylphosphonate |
| TREP-021 | - | dimethyl ((4S)-4-((tetrahydro-2H-pyran-2-yl)oxy)nonyl)phosphonate |
| TREP-022 | 101691-57-0在售 | 5-methoxy-3a,4-dihydronaphtho[2,3-b]furan-2(3H)-one |
| TREP-023 | 101691-99-0在售 | (9aS)-8-methoxy-3-((3S)-3-((tetrahydro-2H-pyran-2-yl)oxy)octyl)-1,4,9,9a-tetrahydro-2H-cyclopenta[b]naphthalen-2-one |
| TREP-024 | 223734-61-0在售 | (3aS,9aS)-5-methoxy-1-((3S)-3-((tetrahydro-2H-pyran-2-yl)oxy)octyl)-1,3,3a,4,9,9a-hexahydro-2H-cyclopenta[b]naphthalen-2-one |
| TREP-025 | 101758-86-5在售 | (1R,3aS,9aS)-5-methoxy-1-((3S)-3-((tetrahydro-2H-pyran-2-yl)oxy)octyl)-1,3,3a,4,9,9a-hexahydro-2H-cyclopenta[b]naphthalen-2-one |
| TREP-026 | 101692-01-7在售 | (1R,2R,3aS,9aS)-1-((S)-3-hydroxyoctyl)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-ol |
| TREP-027 | 101692-02-8在售 | (1R,2R,3aS,9aS)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-2,5-diol |
| TREP-028 | 107-14-2在售 | 2-chloroacetonitrile |
| TREP-029 | 101692-03-9在售 | 2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetonitrile |
优化Route 3步骤 15 · 总收率 76 mg
TREP-024223734-61-0TREP-026101692-01-7TREP-027101692-02-8TREP-029101692-03-9TREP-0306971-51-3TREP-031153974-48-2TREP-032106-95-6TREP-033223734-55-2TREP-034136911-16-5TREP-03594956-98-6TREP-036223734-62-1TREP-037223734-56-3TREP-038223734-57-4TREP-03922348-32-9TREP-040—TREP-041223734-59-6TREP-042223734-60-9TREP-043101758-87-6API · 曲前列尼尔
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| TREP-024 | 223734-61-0在售 | (3aS,9aS)-5-methoxy-1-((3S)-3-((tetrahydro-2H-pyran-2-yl)oxy)octyl)-1,3,3a,4,9,9a-hexahydro-2H-cyclopenta[b]naphthalen-2-one |
| TREP-026 | 101692-01-7在售 | (1R,2R,3aS,9aS)-1-((S)-3-hydroxyoctyl)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-ol |
| TREP-027 | 101692-02-8在售 | (1R,2R,3aS,9aS)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-2,5-diol |
| TREP-029 | 101692-03-9在售 | 2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetonitrile |
| TREP-030 | 6971-51-3在售 | (3-methoxyphenyl)methanol |
| TREP-031 | 153974-48-2在售 | tert-butyl((3-methoxybenzyl)oxy)dimethylsilane |
| TREP-032 | 106-95-6在售 | 3-bromoprop-1-ene |
| TREP-033 | 223734-55-2在售 | ((2-allyl-3-methoxybenzyl)oxy)(tert-butyl)dimethylsilane |
| TREP-034 | 136911-16-5在售 | (2-allyl-3-methoxyphenyl)methanol |
| TREP-035 | 94956-98-6在售 | 2-allyl-3-methoxybenzaldehyde |
| TREP-036 | 223734-62-1在售 | 2-(((S)-dec-1-yn-5-yl)oxy)tetrahydro-2H-pyran |
| TREP-037 | 223734-56-3在售 | (6S)-1-(2-allyl-3-methoxyphenyl)-6-((tetrahydro-2H-pyran-2-yl)oxy)undec-2-yn-1-ol |
| TREP-038 | 223734-57-4在售 | (6S)-1-(2-allyl-3-methoxyphenyl)-6-((tetrahydro-2H-pyran-2-yl)oxy)undec-2-yn-1-one |
| TREP-039 | 22348-32-9在售 | (R)-diphenyl(pyrrolidin-2-yl)methanol |
| TREP-040 | - | (1S,6S)-1-(2-allyl-3-methoxyphenyl)-6-((tetrahydro-2H-pyran-2-yl)oxy)undec-2-yn-1-ol |
| TREP-041 | 223734-59-6在售 | (((1S,6S)-1-(2-allyl-3-methoxyphenyl)-6-((tetrahydro-2H-pyran-2-yl)oxy)undec-2-yn-1-yl)oxy)(tert-butyl)dimethylsilane |
| TREP-042 | 223734-60-9在售 | (4R,9aS)-4-((tert-butyldimethylsilyl)oxy)-8-methoxy-3-((3S)-3-((tetrahydro-2H-pyran-2-yl)oxy)octyl)-1,4,9,9a-tetrahydro-2H-cyclopenta[b]naphthalen-2-one |
| TREP-043 | 101758-87-6在售 | (1R,2R,3aS,9aS)-5-methoxy-1-((3S)-3-((tetrahydro-2H-pyran-2-yl)oxy)octyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-ol |
优化Route 4步骤 24 · 总收率 /
TREP-00996-32-2TREP-027101692-02-8TREP-0306971-51-3TREP-031153974-48-2TREP-032106-95-6TREP-033223734-55-2TREP-034136911-16-5TREP-03594956-98-6TREP-0441613271-09-2TREP-0451776926-15-8TREP-0461613271-12-7TREP-047112022-83-0TREP-0481613271-13-8TREP-0491613271-14-9TREP-0501613271-15-0TREP-0511613271-16-1TREP-0521613271-17-2TREP-0531613271-18-3TREP-0541613271-19-4TREP-055—TREP-0561613271-21-8TREP-0571613271-22-9TREP-0581613271-23-0TREP-0591355990-07-6TREP-06060456-23-7TREP-061124150-87-4TREP-0626224-91-5TREP-0631613271-07-0TREP-0641613271-08-1API · 曲前列尼尔
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| TREP-009 | 96-32-2在售 | methyl 2-bromoacetate |
| TREP-027 | 101692-02-8在售 | (1R,2R,3aS,9aS)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-2,5-diol |
| TREP-030 | 6971-51-3在售 | (3-methoxyphenyl)methanol |
| TREP-031 | 153974-48-2在售 | tert-butyl((3-methoxybenzyl)oxy)dimethylsilane |
| TREP-032 | 106-95-6在售 | 3-bromoprop-1-ene |
| TREP-033 | 223734-55-2在售 | ((2-allyl-3-methoxybenzyl)oxy)(tert-butyl)dimethylsilane |
| TREP-034 | 136911-16-5在售 | (2-allyl-3-methoxyphenyl)methanol |
| TREP-035 | 94956-98-6在售 | 2-allyl-3-methoxybenzaldehyde |
| TREP-044 | 1613271-09-2在售 | (R)-5-(but-3-yn-1-yl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane |
| TREP-045 | 1776926-15-8在售 | (6R)-1-(2-allyl-3-methoxyphenyl)-6,7-bis((tert-butyldimethylsilyl)oxy)hept-2-yn-1-ol |
| TREP-046 | 1613271-12-7在售 | (R)-1-(2-allyl-3-methoxyphenyl)-6,7-bis((tert-butyldimethylsilyl)oxy)hept-2-yn-1-one |
| TREP-047 | 112022-83-0在售 | (R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole |
| TREP-048 | 1613271-13-8在售 | (1S,6R)-1-(2-allyl-3-methoxyphenyl)-6,7-bis((tert-butyldimethylsilyl)oxy)hept-2-yn-1-ol |
| TREP-049 | 1613271-14-9在售 | (5S,10R)-5-(2-allyl-3-methoxyphenyl)-10-((tert-butyldimethylsilyl)oxy)-2,2,3,3,13,13,14,14-octamethyl-4,12-dioxa-3,13-disilapentadec-6-yne |
| TREP-050 | 1613271-15-0在售 | (4R,9aS)-3-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-4-((tert-butyldimethylsilyl)oxy)-8-methoxy-1,4,9,9a-tetrahydro-2H-cyclopenta[b]naphthalen-2-one |
| TREP-051 | 1613271-16-1在售 | (3aS,9aS)-1-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-5-methoxy-1,3,3a,4,9,9a-hexahydro-2H-cyclopenta[b]naphthalen-2-one |
| TREP-052 | 1613271-17-2在售 | (1R,2R,3aS,9aS)-1-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-ol |
| TREP-053 | 1613271-18-3在售 | (R)-5-(2-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)ethyl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane |
| TREP-054 | 1613271-19-4在售 | (R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)butane-1,2-diol |
| TREP-055 | - | - |
| TREP-056 | 1613271-21-8在售 | tert-butyl(((1R,2R,3aS,9aS)-5-methoxy-1-(2-((R)-oxiran-2-yl)ethyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-yl)oxy)diphenylsilane |
| TREP-057 | 1613271-22-9在售 | (S)-1-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)octan-3-ol |
| TREP-058 | 1613271-23-0在售 | (1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-ol |
| TREP-059 | 1355990-07-6在售 | ethyl 2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetate |
| TREP-060 | 60456-23-7在售 | (S)-oxiran-2-ylmethanol |
| TREP-061 | 124150-87-4在售 | (R)-tert-butyldimethyl(oxiran-2-ylmethoxy)silane |
| TREP-062 | 6224-91-5在售 | trimethyl(prop-1-yn-1-yl)silane |
| TREP-063 | 1613271-07-0在售 | (R)-1-((tert-butyldimethylsilyl)oxy)-6-(trimethylsilyl)hex-5-yn-2-ol |
| TREP-064 | 1613271-08-1在售 | (R)-1-((tert-butyldimethylsilyl)oxy)hex-5-yn-2-ol |
优化Route 5步骤 3 · 总收率 2.1 g
TREP-027101692-02-8TREP-0657252-83-7TREP-0661638684-92-0TREP-0671638684-93-1API · 曲前列尼尔
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| TREP-027 | 101692-02-8在售 | (1R,2R,3aS,9aS)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-2,5-diol |
| TREP-065 | 7252-83-7在售 | 2-bromo-1,1-dimethoxyethane |
| TREP-066 | 1638684-92-0在售 | (1R,2R,3aS,9aS)-5-(2,2-dimethoxyethoxy)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-ol |
| TREP-067 | 1638684-93-1在售 | 2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)ethane-1,1-diol |
常见问题（FAQ）
曲前列尼尔的适应症有哪些？
已批准的适应症包括：间质性肺疾病、肺性高血压、肺动脉高压。
曲前列尼尔的专利什么时候到期？
曲前列尼尔的专利到期年暂无公开口径，本页会在数据管道核实后更新。
曲前列尼尔有几条合成路线？
本站收录 5 条合成路线，最短路线 3 步、总收率 2.1 g。每条路线的中间体均带登记编号与 CAS 号。
曲前列尼尔的关键中间体在哪里可以采购？
曲前列尼尔的多条路线中间体已挂接 CAS 档案，其中 60 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取曲前列尼尔中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-09-27