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CAS 109-04-6
2-bromopyridine
登记编号：REMIB-002、COBI-023、VISM-014
应用背景（按来源药适应症）
镇静苯磺酸瑞马唑仑麻醉苯磺酸瑞马唑仑黑色素瘤可美替尼基底细胞癌维莫地吉多发性骨髓瘤维莫地吉淋巴瘤维莫地吉实体瘤维莫地吉血液肿瘤维莫地吉间质软骨肉瘤维莫地吉
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
2-amino-5-bromobenzoic acid→2-bromopyridine→(2-amino-5-bromophenyl)(pyridin-2-yl)methanone→(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-methoxy-5-oxopentanoic acid→methyl (S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-((4-bromo-2-picolinoylphenyl)amino)-5-oxopentanoate→methyl (S)-3-(7-bromo-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanoate→dimorpholinophosphinic chloride→methyl (S)-3-(7-bromo-2-((dimorpholinophosphoryl)oxy)-5-(pyridin-2-yl)-3H-benzo[e][1,4]diazepin-3-yl)propanoate→1-aminopropan-2-ol→methyl 3-((3S)-7-bromo-2-((2-hydroxypropyl)amino)-5-(pyridin-2-yl)-3H-benzo[e][1,4]diazepin-3-yl)propanoate
(S)-tert-butyl 2-(1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate→tert-butyl 3-oxoazetidine-1-carboxylate→2-bromopyridine→tert-butyl 3-hydroxy-3-(pyridin-2-yl)azetidine-1-carboxylate→COBI-025→2,2,2-trifluoro-1-(3-hydroxy-3-(pyridin-2-yl)azetidin-1-yl)ethanone hydrochloride→2,2,2-trifluoro-1-(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)ethanone hydrochloride→tert-butyl 2-(3-hydroxy-1-(2,2,2-trifluoroacetyl)azetidin-3-yl)piperidine-1-carboxylate→tert-butyl 2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate→3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl chloride
2-chloro-4-(methylsulfonyl)benzoyl chloride→4-chlorobenzoic acid→4-chloro-3-iodobenzoic acid→tert-butyl (4-chloro-3-iodophenyl)carbamate→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→tert-butyl (4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate→2-bromopyridine→tert-butyl (4-chloro-3-(pyridin-2-yl)phenyl)carbamate→4-chloro-3-(pyridin-2-yl)aniline
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