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CAS 110351-94-5
(S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
登记编号：BELOH-005
应用背景（按来源药适应症）
非小细胞肺癌盐酸贝洛替康卵巢癌盐酸贝洛替康实体瘤盐酸贝洛替康
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 盐酸贝洛替康Belotecan Hydrochloride | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-(2-nitrophenyl)ethan-1-one→propan-2-amine→benzyl isopropyl(3-(2-nitrophenyl)-3-oxopropyl)carbamate→benzyl (3-(2-aminophenyl)-3-oxopropyl)(isopropyl)carbamate→(S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione→benzyl (S)-(2-(4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-11-yl)ethyl)(isopropyl)carbamate
(S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione→4-ethyl-1,4,7,8-tetrahydro-3H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolane]-3,10-dione→4-ethyl-3-hydroxy-3,4,7,8-tetrahydro-1H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolan]-10-one→4-ethyl-7,8-dihydro-1H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolan]-10-one→(4S)-4-ethyl-3,4-dihydroxy-3,4,7,8-tetrahydro-1H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolan]-10-one→(4S)-4-ethyl-4-hydroxy-10-oxo-4,7,8,10-tetrahydro-1H,3H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolan]-3-yl acetate→(4S)-4-ethyl-4-(methoxymethoxy)-10-oxo-4,7,8,10-tetrahydro-1H,3H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolan]-3-yl acetate→(4S)-4-ethyl-3-hydroxy-4-(methoxymethoxy)-3,4,7,8-tetrahydro-1H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolan]-10-one→(S)-4-ethyl-4-(methoxymethoxy)-1,4,7,8-tetrahydro-3H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolane]-3,10-dione→(S)-4-ethyl-4-hydroxy-1,4,7,8-tetrahydro-3H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolane]-3,10-dione→2-(1,3-dioxolan-2-yl)aniline→(S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
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