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CAS 1190392-23-4
(S)-methyl 4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylate
登记编号：VIBE-013
应用背景（按来源药适应症）
膀胱过度活动症维贝格隆尿失禁维贝格隆
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 维贝格隆Vibegron | Tier C · 观察 / 贸易 | 2031 |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(4S,5R)-tert-butyl 4-formyl-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate→2-(triphenylphosphoranylidene)acetaldehyde→(4R,5R)-tert-butyl 2,2-dimethyl-4-((E)-3-oxoprop-1-en-1-yl)-5-phenyloxazolidine-3-carboxylate→(4R,5R)-tert-butyl 2,2-dimethyl-4-(3-oxopropyl)-5-phenyloxazolidine-3-carboxylate→(4-nitrobenzyl)triphenylphosphonium bromide→(4R,5R)-tert-butyl 2,2-dimethyl-4-((E)-4-(4-nitrophenyl)but-3-en-1-yl)-5-phenyloxazolidine-3-carboxylate→(2R,5S)-tert-butyl 2-((R)-hydroxy(phenyl)methyl)-5-(4-nitrobenzyl)pyrrolidine-1-carboxylate→(2S,5R)-tert-butyl 2-(4-aminobenzyl)-5-((R)-hydroxy(phenyl)methyl)pyrrolidine-1-carboxylate→(S)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylic acid→(2R,5S)-tert-butyl 2-((R)-hydroxy(phenyl)methyl)-5-(4-((S)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxamido)benzyl)pyrrolidine-1-carboxylate→(S)-methyl 5-methoxy-3,4-dihydro-2H-pyrrole-2-carboxylate→3-azatricyclo[4.2.1.02,5]non-7-en-4-one→(S)-methyl 4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylate
3-azatricyclo[4.2.1.02,5]non-7-en-4-one→(S)-methyl 4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylate→pent-4-yn-1-ol→hex-5-ynal→tert-butyl (1-cyanopent-4-yn-1-yl)carbamate→tert-butyl (1-oxo-1-phenylhex-5-yn-2-yl)carbamate→tert-butyl ((1R,2R)-1-hydroxy-1-phenylhex-5-yn-2-yl)carbamate→1-iodo-4-nitrobenzene→(1R,2R)-2-amino-6-(4-nitrophenyl)-1-phenylhex-5-yn-1-ol hydrochloride→(R)-((2R,5S)-5-(4-aminobenzyl)pyrrolidin-2-yl)(phenyl)methanol→(S)-methyl 5-oxopyrrolidine-2-carboxylate
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 |
|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | (6S)-4,6,7,8-tetrahydro-4-oxo-Pyrrolo[1,2-a]pyriMidine-6-carboxylic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | tert-butyl(4-(3-(dimethoxyphosphoryl)-2-oxopropyl)phenyl)carbamate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | (1R,2R)-2-amino-6-(4-nitrophenyl)-1-phenylhex-5-yn-1-olhydrochloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | (R)-((2R,5S)-5-(4-aminobenzyl)pyrrolidin-2-yl)(phenyl)methanol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | tert-butyl(4R,5R)-4-(hydroxymethyl)-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | tert-butyl(4R,5R)-4-((E)-4-(4-((tert-butoxycarbonyl)amino)phenyl)-3-oxobut-1-en-1-yl)-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。