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CAS 1208452-88-3
4-Bromo-3-chloro-7-methoxyquinoline
登记编号：(I)1078735-1-a、(III)1078735-2-a、(I)1078735-3-a
应用背景（按来源药适应症）
乳腺癌甲苯磺酸依仑司群转移性乳腺癌甲苯磺酸依仑司群转移癌甲苯磺酸依仑司群卵巢癌甲苯磺酸依仑司群子宫内膜癌甲苯磺酸依仑司群结直肠癌甲苯磺酸依仑司群
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 甲苯磺酸依仑司群Imlunestrant Tosylate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4-Bromo-3-chloro-7-methoxyquinoline→4-Fluoranylbenzoyl chloride→(3-Chloro-7-methoxyquinolin-4-yl)(4-fluorophenyl)methanone→(3-Chloro-7-hydroxyquinolin-4-yl)(4-fluorophenyl)methanone→2-[3-(Fluoromethyl)azetidin-1-yl]ethan-1-ol hydrogen chloride→(3-Chloro-7-hydroxyquinolin-4-yl)(4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl)methanone→[2-Fluoro-4-(trifluoromethyl)phenyl]boronic acid→(4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]phenyl)[3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone→4-[(4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]phenyl)(hydroxy)methyl]-3-[2-fluoro-4-(trifluoromethyl)phenyl]quinolin-7-ol→5-(4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]phenyl)-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-2-ol→3-(Fluoromethyl)azetidine hydrogen chloride→1,4-Dioxane-2,5-diol→2-[3-(Fluoromethyl)azetidin-1-yl]ethan-1-ol
4-Hydroxy-7-methoxyquinoline→3-Chloro-4-hydroxy-7-methoxyquinoline→4-Bromo-3-chloro-7-methoxyquinoline→(4-Fluorophenyl)methanone→(3-Chloro-7-methoxyquinolin-4-yl)(4-fluorophenyl)methanone→4-Fluoranylbenzoyl chloride→(3-Chloro-7-hydroxyquinolin-4-yl)(4-fluorophenyl)methanone→1,1-Diethoxy-2-hydroxyethane→(3-Chloro-7-hydroxyquinolin-4-yl)[4-(2,2-diethoxyethoxy)phenyl]methanone→[2-Fluoro-4-(trifluoromethyl)phenyl]boronic acid→[4-(2,2-Diethoxyethoxy)phenyl][3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone→(4-Fluorophenyl)[3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone→4-[(R)-[4-(2,2-Diethoxyethoxy)phenyl](hydroxy)methyl]-3-[2-fluoro-4-(trifluoromethyl)phenyl]quinolin-7-ol→(5R)-5-[4-(2,2-Diethoxyethoxy)phenyl]-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-2-ol
4-Bromo-3-chloro-7-methoxyquinoline→4-Fluoro-2,3,5,6-tetradeutero-benzoyl chloride→(3-Chloro-7-methoxyquinolin-4-yl)[4-fluoro-2,3,5,6-tetradeutero-phenyl]methanone→(3-Chloro-7-hydroxyquinolin-4-yl)[4-fluoro-2,3,5,6-tetradeutero-phenyl]methanone→[2-Fluoro-4-(trifluoromethyl)phenyl]boronic acid→[4-Fluoro-2,3,5,6-tetradeutero-phenyl][3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone→2-[3-(Fluoromethyl)azetidin-1-yl]ethan-1-ol→[4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]-2,3,5,6-tetradeutero-phenyl][3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone→4-[[4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]-2,3,5,6-tetradeutero-phenyl](hydroxy)methyl]-3-[2-fluoro-4-(trifluoromethyl)phenyl]quinolin-7-ol→(±)-5-[4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]-2,3,5,6-tetradeutero-phenyl]-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-2-ol
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。