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CAS 1256490-53-5
(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl 4-oxopentanoate
登记编号：SOFO-012
应用背景（按来源药适应症）
丙型肝炎索磷布韦/维帕他韦慢性丙型肝炎索磷布韦/维帕他韦终末期肾脏病索磷布韦/维帕他韦肝脏移植排斥索磷布韦/维帕他韦肾脏移植排斥索磷布韦/维帕他韦心脏衰竭索磷布韦/维帕他韦
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 索磷布韦/维帕他韦Sofosbuvir/Velpatasvir | Tier B · 提前布局 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione→(S)-isopropyl 2-aminopropanoate hydrochloride→1-((2R,3R,4R,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoro-4-hydroxy-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione→4-oxopentanoic anhydride→(2R,3R,4R,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-3-yl 4-oxopentanoate→(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl 4-oxopentanoate→(S)-isopropyl 2-(((R)-(4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate→(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl 4-oxopentanoate→phenol→4-nitrophenyl phosphorodichloridate
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