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CAS 1334395-05-9
(1S,3R,4R,5R)-4-((E)-3-hydroxy-5-phenylpent-1-en-1-yl)-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl dibenzoate
登记编号：BIMA-050
应用背景（按来源药适应症）
高眼压贝美前列素/马来酸噻吗洛尔开角型青光眼贝美前列素/马来酸噻吗洛尔青光眼贝美前列素/马来酸噻吗洛尔高眼压贝美前列素青光眼贝美前列素少毛症贝美前列素开角型青光眼贝美前列素白内障贝美前列素瘢痕贝美前列素
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 贝美前列素/马来酸噻吗洛尔Bimatoprost/Timolol Maleate | Tier C · 观察 / 贸易 | - |
| 贝美前列素Bimatoprost | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
dimethyl (2-oxo-4-phenylbutyl)phosphonate→(4-carboxybutyl)triphenylphosphonium bromide→methyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoate→(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-hydroxyhexahydro-2H-cyclopenta[b]furan-5-yl benzoate→(Z)-7-((1R,2S,3R,5S)-3-(benzoyloxy)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxycyclopentyl)hept-5-enoic acid→(1R,2S,3R,4S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxy-3-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentyl benzoate→(1S,3R,4S,5R)-4-(hydroxymethyl)-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl dibenzoate→(1S,3R,4R,5R)-4-formyl-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl dibenzoate→(1R,3S,4R,5R)-4-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)-5-((E)-3-oxo-5-phenylpent-1-en-1-yl)cyclopentane-1,3-diyl dibenzoate→(1S,3R,4R,5R)-4-((E)-3-hydroxy-5-phenylpent-1-en-1-yl)-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl dibenzoate→4-phenylbutan-2-one→1-bromo-4-phenylbutan-2-one→1-iodo-4-phenylbutan-2-one
dimethyl (2-oxo-4-phenylbutyl)phosphonate→(4-carboxybutyl)triphenylphosphonium bromide→methyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoate→(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-hydroxyhexahydro-2H-cyclopenta[b]furan-5-yl benzoate→(Z)-7-((1R,2S,3R,5S)-3-(benzoyloxy)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxycyclopentyl)hept-5-enoic acid→(1R,2S,3R,4S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxy-3-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentyl benzoate→(1S,3R,4S,5R)-4-(hydroxymethyl)-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl dibenzoate→(1S,3R,4R,5R)-4-formyl-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl dibenzoate→(1R,3S,4R,5R)-4-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)-5-((E)-3-oxo-5-phenylpent-1-en-1-yl)cyclopentane-1,3-diyl dibenzoate→(1S,3R,4R,5R)-4-((E)-3-hydroxy-5-phenylpent-1-en-1-yl)-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl dibenzoate→4-phenylbutan-2-one→1-bromo-4-phenylbutan-2-one→1-iodo-4-phenylbutan-2-one
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