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CAS 139911-29-8
(4-fluoro-2-methylphenyl)boronic acid4-Fluoro-2-methylphenylboronic acid
登记编号：Elinzanetant-010、(VII)448314-1-a、(XV)448314-2-b
应用背景（按来源药适应症）
热潮红依林奈坦血管舒缩症依林奈坦HR阳性乳腺癌依林奈坦睡眠障碍依林奈坦绝经期症状依林奈坦阿片类依赖依林奈坦
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 依林奈坦Elinzanetant | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4-(tert-butoxycarbonyl)morpholine-3-carboxylic acid→tert-butyl 3-(((R)-3-hydroxy-1-methoxy-1-oxopropan-2-yl)carbamoyl)morpholine-4-carboxylate→(7R)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazine-6,9-dione→((7S)-octahydropyrazino[2,1-c][1,4]oxazin-7-yl)methanol→(7S,9aS)-7-(((tert-butyldimethylsilyl)oxy)methyl)octahydropyrazino[2,1-c][1,4]oxazine→2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide→2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-((7S,9aS)-7-(((tert-butyldimethylsilyl)oxy)methyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl)-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide→tert-butyl (6-chloro-4-methylpyridin-3-yl)(methyl)carbamate→6-chloro-N,4-dimethylpyridin-3-amine→(4-fluoro-2-methylphenyl)boronic acid→6-chloro-4-(4-fluoro-2-methylphenyl)-N-methylpyridin-3-amine→2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoyl chloride
3-Amino-6-chloropyridine→1,1-Dimethylethyl (6-Chloro-3-pyridinyl)carbamate→N-(6-Chloro-4-iodopyridin-3-yl)carbamic acid tert-butyl ester→Iodomethane→6-Chloro-4-iodo-N-methyl-N-Boc-pyridin-3-amine→6-Chloro-4-iodo-N-methylpyridin-3-amine→4-Fluoro-2-methylphenylboronic acid→6-Chloro-4-(4-fluoro-2-methylphenyl)-N-methylpyridin-3-amine→2-[3,5-Bis(trifluoromethyl)phenyl]-2-methylpropanoyl chloride→2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-N,2-dimethylpropanamide→(7S,9aS)-7-([[tert-Butyl(dimethyl)silyl]oxy]methyl)octahydropyrazino[2,1-c][1,4]oxazine→2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-[(7S,9aS)-7-([[tert-butyl(dimethyl)silyl]oxy]methyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-N,2-dimethylpropanamide
2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-N,2-dimethylpropanamide→4-Chloro-5-nitropyridin-2(1H)-one→2-[3,5-Bis(trifluoromethyl)phenyl]-2-methylpropanoyl chloride→4-Fluoro-2-methylphenylboronic acid→4-(4-Fluoro-2-methylphenyl)-5-nitropyridin-2(1H)-one→2-Chloro-4-(4-fluoro-2-methylphenyl)-5-nitropyridine→6-Chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-amine hydrogen chloride (1/1)→2-[3,5-Bis(trifluoromethyl)phenyl]-2-methylpropanoic acid→2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-2-methylpropanamide→Iodomethane
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | N-Boc-O-Benzyl-D-serine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-amine hydrochloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | N-[6-Chloro-4-(4-fluoro-2-methylp henyl)-3-pyridinyl]-N,a,a-trimethy Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 3-Morpholinemethanol, 4-(phenylmethyl)-, hydrochloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | (7S,9aS)-7-((Benzyloxy)methyl)octahydropyrazino[2,1-c][1,4]oxazine dioxalate salt Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | ((7S)-octahydropyrazino[2,1-c][1,4]oxazin-7-yl)methanol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 4-Boc-3-morpholinecarboxylic Acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 2-(3,5-bis-trifluoromethylphenyl)-2-methyl-propionyl chloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。