← 返回专利悬崖列表
CAS 142203-65-4
13-Acetyl-9-dihydrobaccatin-III
登记编号：(I)140605-9-a、(I)140605-18-a
应用背景（按来源药适应症）
膀胱癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)头颈癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)头颈部鳞状细胞癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)实体瘤多西他赛纳米胶束 (Samyang Biopharmaceuticals)
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 多西他赛纳米胶束 (Samyang Biopharmaceuticals)Docetaxel polymeric micelle (Samyang Biopharmaceuticals) | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
13-Acetyl-9-dihydrobaccatin-III→(2alpha,5beta,7beta,9beta,10beta,13alpha)-4-(Acetyloxy)-1,7,9,10,13-pentahydroxy-5,20-epoxytax-11-en-2-yl benzoate→(1S,2S,3R,4S,7R,9S,10R,11R,12R,15S)-4-(acetyloxy)-1,11,15-trihydroxy-10,14,17,17-tetramethyl-9,12-bis[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→(4S,5R)-3-[(tert-butoxy)carbonyl]-4-phenyl-1,3-oxazolidine-5-carboxylic acid→5-(1S,2S,3R,4S,7R,9S,10R,11R,12R,15S)-4-(acetyloxy)-2-(benzoyloxy)-1,11-dihydroxy-10,14,17,17-tetramethyl-9,12-bis[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-15-yl 3-tert-butyl (4S,5R)-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate→5-(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-2-(benzoyloxy)-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9,12-bis[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-15-yl 3-tert-butyl (4S,5R)-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(Acetyloxy)-15-[[(2R,3S)-3-amino-2-hydroxy-3-phenylpropanoyl]oxy]-1,9,12-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate
13-Acetyl-9-dihydrobaccatin-III→(2aR,4S,4aR,5R,6R,9S,11S,12S,12aR,12bS)-9,12b-Bis(acetoxy)-5,6,11-trihydroxy-4a,8,13,13-tetramethyl-4-[triethylsilyloxy]-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate→(2aR,4S,4aS,9S,11S,12S,12aR,12bS)-9,12b-Bis(acetoxy)-11-hydroxy-4a,8,13,13-tetramethyl-5,6-dioxo-4-[triethylsilyloxy]-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate→(2aR,4S,4aS,9S,11S,12S,12aR,12bS)-12b-(Acetoxy-9,11-dihydroxy-4a,8,13,13-tetramethyl-5,6-dioxo-4-[triethylsilyloxy]-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate→3(S)-[tert-Butoxycarboxamido]-2(R)-(1-ethoxyethoxy)-3-phenylpropionic acid→3(R)-(1-Ethoxyethoxy)-2-oxo-4(S)-phenylazetidine-1-carboxylic acid tert-butyl ester→(2aR,4S,4aS,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-9-[3-[tert-butoxycarbonylamino]-2(R)-(1-ethoxyethoxy)-3(S)-phenylpropanoyloxy]-11-hydroxy-4a,8,13,13-tetramethyl-5,6-dioxo-4-[triethylsilyloxy]-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。