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CAS 150254-77-6
methyl 3-(2-(((1S,2R,3S,4R)-3-((S)-4-(pentylcarbamoyl)-4,5-dihydrooxazol-2-yl)-7-oxabicyclo[2.2.1]heptan-2-yl)methyl)phenyl)propanoate
登记编号：IFET-009
应用背景（按来源药适应症）
特发性肺纤维化Ifetroban杜氏肌营养不良症Ifetroban扩张型心肌病Ifetroban实体瘤Ifetroban阿司匹林引起的哮喘Ifetroban鼻息肉Ifetroban
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Ifetroban | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(1S,3aR,4R,7S,7aR)-octahydro-4,7-epoxyisobenzofuran-1-ol→(2-(3-((dimethyl(neopentyl)silyl)oxy)propyl)phenyl)magnesium bromide→(S)-(2-(3-((dimethyl(neopentyl)silyl)oxy)propyl)phenyl)((1S,2S,3R,4R)-3-(hydroxymethyl)-7-oxabicyclo[2.2.1]heptan-2-yl)methanol→((1R,2R,3R,4S)-3-(2-(3-((dimethyl(neopentyl)silyl)oxy)propyl)benzyl)-7-oxabicyclo[2.2.1]heptan-2-yl)methanol→methyl 3-(2-(((1S,2R,3R,4R)-3-(hydroxymethyl)-7-oxabicyclo[2.2.1]heptan-2-yl)methyl)phenyl)propanoate→(1R,2S,3R,4S)-3-(2-(3-methoxy-3-oxopropyl)benzyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid→(S)-2-amino-3-hydroxy-N-pentylpropanamide→methyl 3-(2-(((1S,2R,3S,4R)-3-(((S)-3-hydroxy-1-oxo-1-(pentylamino)propan-2-yl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2-yl)methyl)phenyl)propanoate→methyl 3-(2-(((1S,2R,3S,4R)-3-((S)-4-(pentylcarbamoyl)-4,5-dihydrooxazol-2-yl)-7-oxabicyclo[2.2.1]heptan-2-yl)methyl)phenyl)propanoate→methyl 3-(2-(((1S,2R,3S,4R)-3-(4-(pentylcarbamoyl)oxazol-2-yl)-7-oxabicyclo[2.2.1]heptan-2-yl)methyl)phenyl)propanoate
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